Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria

Pedro Mejia*, J. Humberto Treviño-Villarreal*, Mariana De Niz, Elamaran Meibalan, Alban Longchamp, Justin S. Reynolds, Lindsey B. Turnbull, Robert O. Opoka, Christian Roussilhon, Tobias Spielmann, C. Keith Ozaki, Volker T. Heussler, Karl B. Seydel, Terrie E. Taylor, Chandy C. John, Danny A. Milner, Matthias Marti, James R. Mitchell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Circulating levels of the adipokine leptin are linked to neuropathology in experimental cerebral malaria (ECM), but its source and regulation mechanism remain unknown. Here, we show that sequestration of infected red blood cells (iRBCs) in white adipose tissue (WAT) microvasculature increased local vascular permeability and leptin production. Mice infected with parasite strains that fail to sequester in WAT displayed reduced leptin production and protection from ECM. WAT sequestration and leptin induction were lost in CD36KO mice; however, ECM susceptibility revealed sexual dimorphism. Adipocyte leptin was regulated by the mechanistic target of rapamycin complex 1 (mTORC1) and blocked by rapamycin. In humans, although Plasmodium falciparum infection did not increase circulating leptin levels, iRBC sequestration, tissue leptin production, and mTORC1 activity were positively correlated with CM in pediatric postmortem WAT. These data identify WAT sequestration as a trigger for leptin production with potential implications for pathogenesis of malaria infection, prognosis, and treatment.

Original languageEnglish (US)
Article numbereabe2484
JournalScience Advances
Volume7
Issue number13
DOIs
StatePublished - Mar 2021

ASJC Scopus subject areas

  • General

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