Adjuvant chemotherapy after neoadjuvant chemoradiation and surgery: A quest to improve survival for stage II and III rectal cancer

Max Vergo, Halla Nimeiri, Al B. Benson

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Combined multimodality treatments, including radiation, chemotherapy, and total mesorectal excision have been studied extensively over the past few decades, with efforts toward improving rates of locoregional recurrence and disease-free and overall survival in rectal cancer. Predictive and prognostic markers to adjuvant systemic chemotherapy have been identified, with the goal of tailoring therapy and continuing improvement in survival. In our article, we discuss these factors, including tumor downstaging, pathologic node status, gene expression, and future directions in therapy of rectal cancer.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalCurrent Colorectal Cancer Reports
Volume5
Issue number3
DOIs
StatePublished - Jul 1 2009

Fingerprint

Adjuvant Chemotherapy
Rectal Neoplasms
Disease-Free Survival
Therapeutics
Radiation
Gene Expression
Recurrence
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

Cite this

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abstract = "Combined multimodality treatments, including radiation, chemotherapy, and total mesorectal excision have been studied extensively over the past few decades, with efforts toward improving rates of locoregional recurrence and disease-free and overall survival in rectal cancer. Predictive and prognostic markers to adjuvant systemic chemotherapy have been identified, with the goal of tailoring therapy and continuing improvement in survival. In our article, we discuss these factors, including tumor downstaging, pathologic node status, gene expression, and future directions in therapy of rectal cancer.",
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Adjuvant chemotherapy after neoadjuvant chemoradiation and surgery : A quest to improve survival for stage II and III rectal cancer. / Vergo, Max; Nimeiri, Halla; Benson, Al B.

In: Current Colorectal Cancer Reports, Vol. 5, No. 3, 01.07.2009, p. 151-157.

Research output: Contribution to journalReview article

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AU - Benson, Al B.

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AB - Combined multimodality treatments, including radiation, chemotherapy, and total mesorectal excision have been studied extensively over the past few decades, with efforts toward improving rates of locoregional recurrence and disease-free and overall survival in rectal cancer. Predictive and prognostic markers to adjuvant systemic chemotherapy have been identified, with the goal of tailoring therapy and continuing improvement in survival. In our article, we discuss these factors, including tumor downstaging, pathologic node status, gene expression, and future directions in therapy of rectal cancer.

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