Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death

Jessica K. Altman; Alfred Rademaker; Elizabeth Cull; Bing Bing Weitner; Yishai Ofran; Todd L. Rosenblat; Augustin Haidau; Jae H. Park; Sharona Lee Ram; James M. Orsini; Sonia Sandhu; Rosalind Catchatourian; Steven M. Trifilio; Nelly G. Adel; Olga Frankfurt; Eytan M. Stein; George Mallios; Tony Deblasio; Joseph G. Jurcic; Stephen Nimer; Lo Ann C. Peterson; Hau C. Kwaan; Jacob M. Rowe; Dan Douer; Martin S. Tallman

doi:10.1016/j.leukres.2013.05.007

Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death

Jessica K. Altman^*, Alfred Rademaker, Elizabeth Cull, Bing Bing Weitner, Yishai Ofran, Todd L. Rosenblat, Augustin Haidau, Jae H. Park, Sharona Lee Ram, James M. Orsini, Sonia Sandhu, Rosalind Catchatourian, Steven M. Trifilio, Nelly G. Adel, Olga Frankfurt, Eytan M. Stein, George Mallios, Tony Deblasio, Joseph G. Jurcic, Stephen NimerLo Ann C. Peterson, Hau C. Kwaan, Jacob M. Rowe, Dan Douer, Martin S. Tallman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage.

Original language	English (US)
Pages (from-to)	1004-1009
Number of pages	6
Journal	Leukemia Research
Volume	37
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2013.05.007
State	Published - Sep 2013

Keywords

ATRA
Acute Promyelocytic Leukemia
Early Death Rate
Hemorrhage

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2013.05.007

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Altman, J. K., Rademaker, A., Cull, E., Weitner, B. B., Ofran, Y., Rosenblat, T. L., Haidau, A., Park, J. H., Ram, S. L., Orsini, J. M., Sandhu, S., Catchatourian, R., Trifilio, S. M., Adel, N. G., Frankfurt, O., Stein, E. M., Mallios, G., Deblasio, T., Jurcic, J. G., ... Tallman, M. S. (2013). Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death. Leukemia Research, 37(9), 1004-1009. https://doi.org/10.1016/j.leukres.2013.05.007

Altman, Jessica K. ; Rademaker, Alfred ; Cull, Elizabeth ; Weitner, Bing Bing ; Ofran, Yishai ; Rosenblat, Todd L. ; Haidau, Augustin ; Park, Jae H. ; Ram, Sharona Lee ; Orsini, James M. ; Sandhu, Sonia ; Catchatourian, Rosalind ; Trifilio, Steven M. ; Adel, Nelly G. ; Frankfurt, Olga ; Stein, Eytan M. ; Mallios, George ; Deblasio, Tony ; Jurcic, Joseph G. ; Nimer, Stephen ; Peterson, Lo Ann C. ; Kwaan, Hau C. ; Rowe, Jacob M. ; Douer, Dan ; Tallman, Martin S. / Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death. In: Leukemia Research. 2013 ; Vol. 37, No. 9. pp. 1004-1009.

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title = "Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death",

abstract = "We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage.",

keywords = "ATRA, Acute Promyelocytic Leukemia, Early Death Rate, Hemorrhage",

author = "Altman, {Jessica K.} and Alfred Rademaker and Elizabeth Cull and Weitner, {Bing Bing} and Yishai Ofran and Rosenblat, {Todd L.} and Augustin Haidau and Park, {Jae H.} and Ram, {Sharona Lee} and Orsini, {James M.} and Sonia Sandhu and Rosalind Catchatourian and Trifilio, {Steven M.} and Adel, {Nelly G.} and Olga Frankfurt and Stein, {Eytan M.} and George Mallios and Tony Deblasio and Jurcic, {Joseph G.} and Stephen Nimer and Peterson, {Lo Ann C.} and Kwaan, {Hau C.} and Rowe, {Jacob M.} and Dan Douer and Tallman, {Martin S.}",

year = "2013",

month = sep,

doi = "10.1016/j.leukres.2013.05.007",

language = "English (US)",

volume = "37",

pages = "1004--1009",

journal = "Leukemia Research",

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Altman, JK , Rademaker, A, Cull, E, Weitner, BB, Ofran, Y, Rosenblat, TL, Haidau, A, Park, JH, Ram, SL, Orsini, JM, Sandhu, S, Catchatourian, R, Trifilio, SM, Adel, NG, Frankfurt, O, Stein, EM, Mallios, G, Deblasio, T, Jurcic, JG, Nimer, S, Peterson, LAC , Kwaan, HC, Rowe, JM, Douer, D & Tallman, MS 2013, 'Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death', Leukemia Research, vol. 37, no. 9, pp. 1004-1009. https://doi.org/10.1016/j.leukres.2013.05.007

Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death. / Altman, Jessica K.; Rademaker, Alfred; Cull, Elizabeth; Weitner, Bing Bing; Ofran, Yishai; Rosenblat, Todd L.; Haidau, Augustin; Park, Jae H.; Ram, Sharona Lee; Orsini, James M.; Sandhu, Sonia; Catchatourian, Rosalind; Trifilio, Steven M.; Adel, Nelly G.; Frankfurt, Olga; Stein, Eytan M.; Mallios, George; Deblasio, Tony; Jurcic, Joseph G.; Nimer, Stephen; Peterson, Lo Ann C.; Kwaan, Hau C.; Rowe, Jacob M.; Douer, Dan; Tallman, Martin S.

In: Leukemia Research, Vol. 37, No. 9, 09.2013, p. 1004-1009.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death

AU - Altman, Jessica K.

AU - Rademaker, Alfred

AU - Cull, Elizabeth

AU - Weitner, Bing Bing

AU - Ofran, Yishai

AU - Rosenblat, Todd L.

AU - Haidau, Augustin

AU - Park, Jae H.

AU - Ram, Sharona Lee

AU - Orsini, James M.

AU - Sandhu, Sonia

AU - Catchatourian, Rosalind

AU - Trifilio, Steven M.

AU - Adel, Nelly G.

AU - Frankfurt, Olga

AU - Stein, Eytan M.

AU - Mallios, George

AU - Deblasio, Tony

AU - Jurcic, Joseph G.

AU - Nimer, Stephen

AU - Peterson, Lo Ann C.

AU - Kwaan, Hau C.

AU - Rowe, Jacob M.

AU - Douer, Dan

AU - Tallman, Martin S.

PY - 2013/9

Y1 - 2013/9

N2 - We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage.

AB - We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage.

KW - ATRA

KW - Acute Promyelocytic Leukemia

KW - Early Death Rate

KW - Hemorrhage

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UR - http://www.scopus.com/inward/citedby.url?scp=84880964268&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2013.05.007

DO - 10.1016/j.leukres.2013.05.007

M3 - Article

C2 - 23768930

AN - SCOPUS:84880964268

VL - 37

SP - 1004

EP - 1009

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 9

ER -

Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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