Abstract
We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage.
Original language | English (US) |
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Pages (from-to) | 1004-1009 |
Number of pages | 6 |
Journal | Leukemia Research |
Volume | 37 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2013 |
Keywords
- ATRA
- Acute Promyelocytic Leukemia
- Early Death Rate
- Hemorrhage
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research