TY - JOUR
T1 - Administration of Single-Dose Antibiotic Does Not Decrease Oronasal Fistula Rates After Primary Palatoplasty
AU - Mamidi, Ishwarya Shradha
AU - Mantilla-Rivas, Esperanza
AU - Ichiuji, Brynne A.
AU - Rana, Md Sohel
AU - Ramirez, Karen I.
AU - Stein, Jason R.
AU - Aivaz, Marudeen
AU - Manrique, Monica
AU - McGrath, Jennifer
AU - Rogers, Gary F.
AU - Oh, Albert K.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was performed without commercial support or sponsorship.
Publisher Copyright:
© 2021, American Cleft Palate-Craniofacial Association.
PY - 2022/1
Y1 - 2022/1
N2 - Objective: Oronasal fistula (ONF) is a known complication after primary palatoplasty (PP). Studies investigating the effect of perioperative antibiotics on fistula rates after PP are limited by inadequate sample size or reliance on self-reporting through national databases. In this study, the authors evaluated the association between single-dose perioperative antibiotics and postoperative fistula rates after PP at a single institution. Design: A retrospective study. Participants: Children younger than 2 years who underwent PP from April 2009 to September 2019 were included. Interventions: Patients were divided into 2 categories: Group 1 received a single intraoperative dose of IV antibiotic, while group 2 did not. Main Outcome Measure(s): Outcome measures included ONF formation, length of stay (LOS), and 30-day readmission rates. Multivariable firth logistic regression, quantile regression, and χ2 tests were performed. Results: Of the 424 patients, 215 and 209 patients were in groups 1 and 2, respectively. The overall ONF rate was 1.9% among all patients. Patients in group 1 experienced an ONF rate of 3.3%, while patients in group 2 had an ONF rate of 0.5%. After correcting for confounding variables, the difference in ONF rates was not statistically different (P =.68). Median LOS was 35.7 hours and 35.5 hours (P =.17), while the rate of readmission within 30 days was 4.7% and 2.4% for group 1 and 2, respectively (P =.96). Conclusions: Administration of a single-dose perioperative antibiotic did not decrease fistula formation after PP, nor did it affect the patient’s LOS or 30-day readmission rate.
AB - Objective: Oronasal fistula (ONF) is a known complication after primary palatoplasty (PP). Studies investigating the effect of perioperative antibiotics on fistula rates after PP are limited by inadequate sample size or reliance on self-reporting through national databases. In this study, the authors evaluated the association between single-dose perioperative antibiotics and postoperative fistula rates after PP at a single institution. Design: A retrospective study. Participants: Children younger than 2 years who underwent PP from April 2009 to September 2019 were included. Interventions: Patients were divided into 2 categories: Group 1 received a single intraoperative dose of IV antibiotic, while group 2 did not. Main Outcome Measure(s): Outcome measures included ONF formation, length of stay (LOS), and 30-day readmission rates. Multivariable firth logistic regression, quantile regression, and χ2 tests were performed. Results: Of the 424 patients, 215 and 209 patients were in groups 1 and 2, respectively. The overall ONF rate was 1.9% among all patients. Patients in group 1 experienced an ONF rate of 3.3%, while patients in group 2 had an ONF rate of 0.5%. After correcting for confounding variables, the difference in ONF rates was not statistically different (P =.68). Median LOS was 35.7 hours and 35.5 hours (P =.17), while the rate of readmission within 30 days was 4.7% and 2.4% for group 1 and 2, respectively (P =.96). Conclusions: Administration of a single-dose perioperative antibiotic did not decrease fistula formation after PP, nor did it affect the patient’s LOS or 30-day readmission rate.
KW - antibiotics
KW - oronasal fistula
KW - palatoplasty
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U2 - 10.1177/1055665621992653
DO - 10.1177/1055665621992653
M3 - Article
C2 - 33583204
AN - SCOPUS:85100908199
VL - 59
SP - 14
EP - 21
JO - Cleft Palate Journal
JF - Cleft Palate Journal
SN - 1055-6656
IS - 1
ER -