Adolescent endogenous sex hormones and breast density in early adulthood

Seungyoun Jung; Brian L. Egleston; D. Walt Chandler; Linda Van Horn; Nola M. Hylton; Catherine C. Klifa; Norman L. Lasser; Erin S. LeBlanc; Kenneth Paris; John A. Shepherd; Linda G. Snetselaar; Frank Z. Stanczyk; Victor J. Stevens; Joanne F. Dorgan

doi:10.1186/s13058-015-0581-4

Adolescent endogenous sex hormones and breast density in early adulthood

Seungyoun Jung, Brian L. Egleston, D. Walt Chandler, Linda Van Horn, Nola M. Hylton, Catherine C. Klifa, Norman L. Lasser, Erin S. LeBlanc, Kenneth Paris, John A. Shepherd, Linda G. Snetselaar, Frank Z. Stanczyk, Victor J. Stevens, Joanne F. Dorgan^*

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction: During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer. Methods: Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV. Results: Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all P_trend ≤0.03) but not when measured in postmenarche samples (all P_trend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all P_trend ≥0.16). Conclusions: Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown. Clinical trials registration: ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

Original language	English (US)
Article number	77
Journal	Breast Cancer Research
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s13058-015-0581-4
State	Published - Jun 4 2015

Funding

This work was supported by US National Institutes of Health (NIH) grants (R03 CA167764 to J.F. Dorgan, R01 CA104670 to J.F. Dorgan, R01 CA116182 to N.M. Hylton, and P30 CA134274 to K.J. Cullen). We thank the institutional review board at Maryland Medical Research Institute, University of Maryland Baltimore, MD, Fox Chase Cancer Center, Philadelphia, PA and the following six clinical centers: Children’s Hospital, New Orleans, LA; Johns Hopkins University Hospital, Baltimore, MD; Kaiser Permanente Center for Health Research, Portland, OR; University of Medicine and Dentistry of New Jersey, Newark, NJ; Northwestern University Medical School, Chicago, IL; and University of Iowa Hospital and Clinics, Iowa City, IA. We are grateful to all participants in the DISC06 study and collaborators for their invaluable contributions.

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13058-015-0581-4

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Jung, S., Egleston, B. L., Chandler, D. W., Van Horn, L., Hylton, N. M., Klifa, C. C., Lasser, N. L., LeBlanc, E. S., Paris, K., Shepherd, J. A., Snetselaar, L. G., Stanczyk, F. Z., Stevens, V. J., & Dorgan, J. F. (2015). Adolescent endogenous sex hormones and breast density in early adulthood. Breast Cancer Research, 17(1), Article 77. https://doi.org/10.1186/s13058-015-0581-4

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title = "Adolescent endogenous sex hormones and breast density in early adulthood",

abstract = "Introduction: During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer. Methods: Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV. Results: Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all Ptrend ≤0.03) but not when measured in postmenarche samples (all Ptrend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all Ptrend ≥0.16). Conclusions: Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown. Clinical trials registration: ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.",

author = "Seungyoun Jung and Egleston, {Brian L.} and Chandler, {D. Walt} and {Van Horn}, Linda and Hylton, {Nola M.} and Klifa, {Catherine C.} and Lasser, {Norman L.} and LeBlanc, {Erin S.} and Kenneth Paris and Shepherd, {John A.} and Snetselaar, {Linda G.} and Stanczyk, {Frank Z.} and Stevens, {Victor J.} and Dorgan, {Joanne F.}",

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doi = "10.1186/s13058-015-0581-4",

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AU - Jung, Seungyoun

AU - Egleston, Brian L.

AU - Chandler, D. Walt

AU - Van Horn, Linda

AU - Hylton, Nola M.

AU - Klifa, Catherine C.

AU - Lasser, Norman L.

AU - LeBlanc, Erin S.

AU - Paris, Kenneth

AU - Shepherd, John A.

AU - Snetselaar, Linda G.

AU - Stanczyk, Frank Z.

AU - Stevens, Victor J.

AU - Dorgan, Joanne F.

PY - 2015/6/4

Y1 - 2015/6/4

N2 - Introduction: During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer. Methods: Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV. Results: Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all Ptrend ≤0.03) but not when measured in postmenarche samples (all Ptrend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all Ptrend ≥0.16). Conclusions: Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown. Clinical trials registration: ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

AB - Introduction: During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer. Methods: Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV. Results: Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all Ptrend ≤0.03) but not when measured in postmenarche samples (all Ptrend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all Ptrend ≥0.16). Conclusions: Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown. Clinical trials registration: ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

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Adolescent endogenous sex hormones and breast density in early adulthood

Abstract

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ASJC Scopus subject areas

UN SDGs

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