Adolescent health-related quality of life following liver and kidney transplantation

S. S. Sundaram, J. M. Landgraf, K. Neighbors, Richard A Cohn, Estella M Alonso*

*Corresponding author for this work

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Health perceptions of adolescent transplant patients should be considered in providing appropriate healthcare. Objectives: (i) quantify health-related quality of life (HRQOL) in adolescent liver and kidney transplant patients, (ii) compare caregiver ratings of their children's HRQOL to adolescent self-reports and (iii) examine the relationship between HRQOL and disease-specific disability (DSD). Adolescent liver (n = 51) and kidney (n = 26) transplant recipients and caregivers were surveyed using the CHQ-CF87 and CHQ-PF50. DSD scores were calculated for each patient. The response rate was >70%. Adolescent's psychological and physical health was similar to a healthy population, but general health poorer (p = 0.0006). Caretakers reported lower physical functioning and general health (p = 0.0001) but similar psychological health to a normative population. All caregivers expressed negative emotional impact of their child's health on themselves and family activities (p = 0.0001). Positive correlations were found between liver transplant recipients and caregivers: perceptions of behavior (ICC = 0.55, p < 0.001), mental health (ICC = 0.56, p < 0.001), self-esteem (ICC = 0.68, p ≤0.001). Positive correlations were found for kidney transplant patients and caregivers: physical function (ICC = 0.85, p < 0.001), bodily pain (ICC = 0.70, p < 0.001), behavior (ICC = 0.67, p < 0.01). Kidney transplant recipients showed negative correlations between physical functioning (R = -0.76, p = 0.0003) and general health (R = -0.60, p = 0.008) with overall DSD. Physical and psychological functioning of adolescent liver and kidney transplant patients is high. Caregivers may serve as adequate proxies of psychological but not physical health.

Original languageEnglish (US)
Pages (from-to)982-989
Number of pages8
JournalAmerican Journal of Transplantation
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2007

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Keywords

  • Adolescence
  • Kidney transplantation
  • Liver transplantation
  • Quality of life

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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