Adoptive B cell therapy for chronic viral infection

Young Rock Chung, Tanushree Dangi, Nicole Palacio, Sarah Sanchez, Pablo Penaloza-MacMaster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


T cell-based therapies have been widely explored for the treatment of cancer and chronic infection, but B cell-based therapies have remained largely unexplored. To study the effect of B cell therapy, we adoptively transferred virus-specific B cells into mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV). Adoptive transfer of virus-specific B cells resulted in increase in antibody titers and reduction of viral loads. Importantly, the efficacy of B cell therapy was partly dependent on antibody effector functions, and was improved by co-transferring virus-specific CD4 T cells. These findings provide a proof-of-concept that adoptive B cell therapy can be effective for the treatment of chronic infections, but provision of virus-specific CD4 T cells may be critical for optimal virus neutralization.

Original languageEnglish (US)
Article number908707
JournalFrontiers in immunology
StatePublished - Jul 26 2022


  • B cells
  • adoptive cell therapy
  • chronic viral infection
  • lymphocytic choriomeningitis virus (LCMV)
  • virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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