Adoptive immunotherapy for leukemia: Donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction

Jr Link C.J., R. K. Burt, A. E. Traynor, W. R. Drobyski, T. Seregina, J. P. Levy, L. Gordon, S. T. Rosen, W. H. Burns, B. Camitta, J. Casper, M. Horowitz, M. Juckett, C. Lawton, D. Margolis, D. Pietryga, P. Rowlings, C. Taylor, M. Furtado, J. StefkaS. Gupta-Burt, H. Kaiser, D. H. Vesole

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Title: Adoptive Immunotherapy for Relapsed Leukemia: Donor Lymphocytes Transduced with the Herpes Simplex Thymidine Kinase Gene for Remission Induction. Primary Objective: To determine the safety of administration of Herpes simplex thymidine kinase transduced donor lymphocytes after allogeneic bone marrow transplantation (BMT) for relapsed hematologic malignancies. Secondary Objective: To determine the toxicity and efficacy associated with the administration of ganciclovir to prevent graft versus host disease (GvHD) induced by the donor lymphocytes. Population: Patients ≤ 2 years of age with relapsed hematologic malignancies after allogeneic BMT. Sample Size: Forty patients. Treatment Dosage: HStk gene modified donor lymphocytes will be administered at either 0.1-2.5 x 108 T cells/kg in recipients of HLA-identical sibling grafts or 0.01-1.0 x 108 T cells/kg in recipients of HLA-mismatched related or HLA-unrelated marrow grafts. GvHD which is progressive or unresponsive to conventional therapy (i.e., steroids with or without cyclosporine) after 72 hours will be treated with ganciclovir given by IV infusion over 1 hour, 5 mg/kg b.i.d. for up to 21 days. Endpoints: Safety and toxicity of donor lymphocyte infusions. Efficacy endpoints: Malignancy remission induction, duration and survival, remission of GvHD.

Original languageEnglish (US)
Pages (from-to)115-134
Number of pages20
JournalHuman Gene Therapy
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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