Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate

Janet A. Stockheim; Jorge J. Daaboul; Ram Yogev; Susan P. Scully; Helen Binns; Ellen Chadwick

doi:10.1016/S0022-3476(99)70467-1

Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate

Janet A. Stockheim^*, Jorge J. Daaboul, Ram Yogev, Susan P. Scully, Helen Binns, Ellen Chadwick

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Symptoms and laboratory evidence of adrenal suppression developed in 2 children with the human immunodeficiency virus after megestrol acetate (MA) therapy was discontinued; both required transient glucocorticoid replacement therapy. High-dose corticotropin stimulation testing performed on children with the human immunodeficiency virus treated or not treated with MA showed that baseline and post-corticotropin cortisol levels were extremely low in 7 of 10 treated patients and normal in 10 of 10 members of a control group (P < .01). MA may suppress adrenal function, and replacement glucocorticoids may prevent or relieve associated symptoms at times of severe stress or on discontinuation of MA therapy.

Original language	English (US)
Pages (from-to)	368-370
Number of pages	3
Journal	Journal of Pediatrics
Volume	134
Issue number	3
DOIs	https://doi.org/10.1016/S0022-3476(99)70467-1
State	Published - 1999

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate",

abstract = "Symptoms and laboratory evidence of adrenal suppression developed in 2 children with the human immunodeficiency virus after megestrol acetate (MA) therapy was discontinued; both required transient glucocorticoid replacement therapy. High-dose corticotropin stimulation testing performed on children with the human immunodeficiency virus treated or not treated with MA showed that baseline and post-corticotropin cortisol levels were extremely low in 7 of 10 treated patients and normal in 10 of 10 members of a control group (P < .01). MA may suppress adrenal function, and replacement glucocorticoids may prevent or relieve associated symptoms at times of severe stress or on discontinuation of MA therapy.",

author = "Stockheim, {Janet A.} and Daaboul, {Jorge J.} and Ram Yogev and Scully, {Susan P.} and Helen Binns and Ellen Chadwick",

note = "Funding Information: Drs Stockheim and Chadwick received financial support from Bristol-Myers Squibb, the maker of Megace, to present this research in abstract form at the Fifth Conference on Retroviruses and Opportunistic Infections, Chicago, Illinois, February 1-5, 1998. ",

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AU - Daaboul, Jorge J.

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AU - Binns, Helen

AU - Chadwick, Ellen

N1 - Funding Information: Drs Stockheim and Chadwick received financial support from Bristol-Myers Squibb, the maker of Megace, to present this research in abstract form at the Fifth Conference on Retroviruses and Opportunistic Infections, Chicago, Illinois, February 1-5, 1998.

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AB - Symptoms and laboratory evidence of adrenal suppression developed in 2 children with the human immunodeficiency virus after megestrol acetate (MA) therapy was discontinued; both required transient glucocorticoid replacement therapy. High-dose corticotropin stimulation testing performed on children with the human immunodeficiency virus treated or not treated with MA showed that baseline and post-corticotropin cortisol levels were extremely low in 7 of 10 treated patients and normal in 10 of 10 members of a control group (P < .01). MA may suppress adrenal function, and replacement glucocorticoids may prevent or relieve associated symptoms at times of severe stress or on discontinuation of MA therapy.

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Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate

Abstract

ASJC Scopus subject areas

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