Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate

Janet A. Stockheim*, Jorge J. Daaboul, Ram Yogev, Susan P. Scully, Helen Binns, Ellen Chadwick

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Symptoms and laboratory evidence of adrenal suppression developed in 2 children with the human immunodeficiency virus after megestrol acetate (MA) therapy was discontinued; both required transient glucocorticoid replacement therapy. High-dose corticotropin stimulation testing performed on children with the human immunodeficiency virus treated or not treated with MA showed that baseline and post-corticotropin cortisol levels were extremely low in 7 of 10 treated patients and normal in 10 of 10 members of a control group (P < .01). MA may suppress adrenal function, and replacement glucocorticoids may prevent or relieve associated symptoms at times of severe stress or on discontinuation of MA therapy.

Original languageEnglish (US)
Pages (from-to)368-370
Number of pages3
JournalJournal of Pediatrics
Volume134
Issue number3
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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