Adrenergic and non-adrenergic neurons in the C1 and C3 areas project to locus coeruleus: A fluorescent double labeling study

Vincent A. Pieribone*, Gary Aston-Jones, Martha C. Bohn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Following iontophoretic injections of the retrograde tracer Fluoro-gold into the rat locus coeruleus (LC), retrogradely labeled neurons were seen predominantly in the area of C1 adrenergic neurons in the ventrolateral medulla (nucleus paragigantocellularis; PGi) and in the area of C3 adrenergic neurons in the dorsomedial medulla (nucleus prepositus hypoglossi; PrH). Subsequent immunofluorescence for phenylethanolamine-N-methytransferase indicated that adrenergic and non-adrenergic LC projecting neurons in both areas are interdigitated, and that 21% of LC afferent neurons in the PGi are adrenergic while only 4% of LC afferent neurons in the area of PrH are adrenergic.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalNeuroscience Letters
Volume85
Issue number3
DOIs
StatePublished - Mar 10 1988

Keywords

  • Adrenaline
  • Adrenergic
  • Afferent pathway
  • C1
  • C2
  • C3
  • Fluoro-gold
  • Locus ceruleus
  • Paragigantocellularis
  • prepositus hypoglossi

ASJC Scopus subject areas

  • Neuroscience(all)

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