Adrenocortical tumours in children and adults: A study of pathological and proliferation features

Simone Treiger Sredni; Venâncio Avancini Ferreira Alves; Maria Do Rosário Latorre; Maria Claudia Nogueira Zerbini

doi:10.1080/00313020307569

Adrenocortical tumours in children and adults: A study of pathological and proliferation features

Simone Treiger Sredni^*, Venâncio Avancini Ferreira Alves, Maria Do Rosário Latorre, Maria Claudia Nogueira Zerbini

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Aims: To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. Methods: Seventy-six cases of ACT were evaluated comparing tumours of children (≤15 years, n=24) and adults (≥15 years, n=52) regarding morphological features and proliferation rates. These parameters were also compared in clinically benign (CB) and clinically malignant (CM) tumours. Tumours were analysed according to Weiss' histological parameters. Proliferation rates were assessed by MIB-1 labelling index and silver binding nucleolar organiser regions (AgNORs) were quantified by image analysis. Results: ACTs in children presented higher proliferative activity than in adults. In adult's ACTs, MIB-1 labelling index (cut-off, 10%) (P=0.037) and the AgNOR pattern (P<0.001) had influence over the disease-free survival (DFS). The AgNOR pattern type I was associated with CB-ACT and the AgNOR pattern type II with CM-ACT. The AgNOR pattern type III was characteristic of children's ACTs and type IV was characteristic of non-neoplasic adrenal glands. Conclusion: ACTs in children had a different morphological spectrum and higher proliferative activity than those tumours in adults, which should be always analysed as a separate group. In adults, our findings reinforce that the morphological criteria proposed by Weiss are an efficient way of differentiating CB-ACT from CM-ACT.

Original language	English (US)
Pages (from-to)	130-135
Number of pages	6
Journal	Pathology
Volume	35
Issue number	2
DOIs	https://doi.org/10.1080/00313020307569
State	Published - Apr 2003

Funding

ACKNOWLEDGEMENTS The authors thank Adhemar L. Filho, Department of Pathology, Adolpho Lutz Institute, Sao Paulo, Brazil, for permission to use the Image Analyzer Laboratory facilities; Ney S. Araujo and Vera C. Araujo, Department of Pathology, University of Sao Paulo's Dentistry School, for permission to use the Research Laboratory of Pathology; Cristina A. Martins and S6nia S. L. Silva for technical support; and Jacques Sredni for English review. This study was supported by FAPESP (Grant 96/2272-0), and FMUSP Foundation.

Keywords

Adrenocortical tumours
AgNOR
Image analysis
MIB-1
Pathology
Prognosis
Proliferation

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1080/00313020307569

Cite this

@article{67abcaf274944ed4875b83a0fb303532,

title = "Adrenocortical tumours in children and adults: A study of pathological and proliferation features",

abstract = "Aims: To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. Methods: Seventy-six cases of ACT were evaluated comparing tumours of children (≤15 years, n=24) and adults (≥15 years, n=52) regarding morphological features and proliferation rates. These parameters were also compared in clinically benign (CB) and clinically malignant (CM) tumours. Tumours were analysed according to Weiss' histological parameters. Proliferation rates were assessed by MIB-1 labelling index and silver binding nucleolar organiser regions (AgNORs) were quantified by image analysis. Results: ACTs in children presented higher proliferative activity than in adults. In adult's ACTs, MIB-1 labelling index (cut-off, 10%) (P=0.037) and the AgNOR pattern (P<0.001) had influence over the disease-free survival (DFS). The AgNOR pattern type I was associated with CB-ACT and the AgNOR pattern type II with CM-ACT. The AgNOR pattern type III was characteristic of children's ACTs and type IV was characteristic of non-neoplasic adrenal glands. Conclusion: ACTs in children had a different morphological spectrum and higher proliferative activity than those tumours in adults, which should be always analysed as a separate group. In adults, our findings reinforce that the morphological criteria proposed by Weiss are an efficient way of differentiating CB-ACT from CM-ACT.",

keywords = "Adrenocortical tumours, AgNOR, Image analysis, MIB-1, Pathology, Prognosis, Proliferation",

author = "Sredni, {Simone Treiger} and {Ferreira Alves}, {Ven{\^a}ncio Avancini} and {Ros{\'a}rio Latorre}, {Maria Do} and {Nogueira Zerbini}, {Maria Claudia}",

note = "Funding Information: ACKNOWLEDGEMENTS The authors thank Adhemar L. Filho, Department of Pathology, Adolpho Lutz Institute, Sao Paulo, Brazil, for permission to use the Image Analyzer Laboratory facilities; Ney S. Araujo and Vera C. Araujo, Department of Pathology, University of Sao Paulo's Dentistry School, for permission to use the Research Laboratory of Pathology; Cristina A. Martins and S6nia S. L. Silva for technical support; and Jacques Sredni for English review. This study was supported by FAPESP (Grant 96/2272-0), and FMUSP Foundation.",

year = "2003",

month = apr,

doi = "10.1080/00313020307569",

language = "English (US)",

volume = "35",

pages = "130--135",

journal = "Pathology",

issn = "0031-3025",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Adrenocortical tumours in children and adults

T2 - A study of pathological and proliferation features

AU - Sredni, Simone Treiger

AU - Ferreira Alves, Venâncio Avancini

AU - Rosário Latorre, Maria Do

AU - Nogueira Zerbini, Maria Claudia

N1 - Funding Information: ACKNOWLEDGEMENTS The authors thank Adhemar L. Filho, Department of Pathology, Adolpho Lutz Institute, Sao Paulo, Brazil, for permission to use the Image Analyzer Laboratory facilities; Ney S. Araujo and Vera C. Araujo, Department of Pathology, University of Sao Paulo's Dentistry School, for permission to use the Research Laboratory of Pathology; Cristina A. Martins and S6nia S. L. Silva for technical support; and Jacques Sredni for English review. This study was supported by FAPESP (Grant 96/2272-0), and FMUSP Foundation.

PY - 2003/4

Y1 - 2003/4

N2 - Aims: To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. Methods: Seventy-six cases of ACT were evaluated comparing tumours of children (≤15 years, n=24) and adults (≥15 years, n=52) regarding morphological features and proliferation rates. These parameters were also compared in clinically benign (CB) and clinically malignant (CM) tumours. Tumours were analysed according to Weiss' histological parameters. Proliferation rates were assessed by MIB-1 labelling index and silver binding nucleolar organiser regions (AgNORs) were quantified by image analysis. Results: ACTs in children presented higher proliferative activity than in adults. In adult's ACTs, MIB-1 labelling index (cut-off, 10%) (P=0.037) and the AgNOR pattern (P<0.001) had influence over the disease-free survival (DFS). The AgNOR pattern type I was associated with CB-ACT and the AgNOR pattern type II with CM-ACT. The AgNOR pattern type III was characteristic of children's ACTs and type IV was characteristic of non-neoplasic adrenal glands. Conclusion: ACTs in children had a different morphological spectrum and higher proliferative activity than those tumours in adults, which should be always analysed as a separate group. In adults, our findings reinforce that the morphological criteria proposed by Weiss are an efficient way of differentiating CB-ACT from CM-ACT.

AB - Aims: To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. Methods: Seventy-six cases of ACT were evaluated comparing tumours of children (≤15 years, n=24) and adults (≥15 years, n=52) regarding morphological features and proliferation rates. These parameters were also compared in clinically benign (CB) and clinically malignant (CM) tumours. Tumours were analysed according to Weiss' histological parameters. Proliferation rates were assessed by MIB-1 labelling index and silver binding nucleolar organiser regions (AgNORs) were quantified by image analysis. Results: ACTs in children presented higher proliferative activity than in adults. In adult's ACTs, MIB-1 labelling index (cut-off, 10%) (P=0.037) and the AgNOR pattern (P<0.001) had influence over the disease-free survival (DFS). The AgNOR pattern type I was associated with CB-ACT and the AgNOR pattern type II with CM-ACT. The AgNOR pattern type III was characteristic of children's ACTs and type IV was characteristic of non-neoplasic adrenal glands. Conclusion: ACTs in children had a different morphological spectrum and higher proliferative activity than those tumours in adults, which should be always analysed as a separate group. In adults, our findings reinforce that the morphological criteria proposed by Weiss are an efficient way of differentiating CB-ACT from CM-ACT.

KW - Adrenocortical tumours

KW - AgNOR

KW - Image analysis

KW - MIB-1

KW - Pathology

KW - Prognosis

KW - Proliferation

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JF - Pathology

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ER -

Adrenocortical tumours in children and adults: A study of pathological and proliferation features

Abstract

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