Adult toxicology in critical care: Part I: General approach to the intoxicated patient

Babak Mokhlesi*, Jerrold B. Leiken, Patrick Murray, Thomas C. Corbridge

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Intensivists are confronted with poisoned patients on a routine basis, with clinical scenarios ranging from known drug overdose or toxic exposure, illicit drug use, suicide attempt, or accidental exposure. In addition, drug toxicity can also manifest in hospitalized patients from inappropriate dosing and drug interactions. In this review article, we describe the epidemiology of poisoning in the United States, review physical examination findings and laboratory data that may aid the intensivist in recognizing a toxidrome (symptom complex of specific poisoning) or specific poisoning, and describe a rational and systematic approach to the poisoned patient. It is important to recognize that there is a paucity of evidence-based information on the management of poisoned patient. However, the most current recommendations by the American Academy of Clinical Toxicology and European Association of Poisons Centers and Clinical Toxicologists will be reviewed. Specific poisonings will be reviewed in the second section of these review articles.

Original languageEnglish (US)
Pages (from-to)577-592
Number of pages16
Issue number2
StatePublished - Feb 1 2003


  • Critical care
  • ICU
  • Poisoning
  • Toxicology
  • Toxidromes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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