Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine

Xinlong Wang, Nancy Rivera-Bolanos, Bin Jiang*, Guillermo Antonio Ameer

*Corresponding author for this work

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Stem cell–based therapies can potentially regenerate many types of tissues and organs, thereby providing solutions to a variety of diseases and injuries. However, acute cell death, uncontrolled differentiation, and low functional engraftment yields remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation, and integration to host tissues may potentially transform the clinical outcome of stem cell–based regenerative therapies. In this review, the authors briefly summarize sources of stem cells for transplantation, present the current state of the art in biomaterial design for stem cell delivery, and provide critical analysis for existing materials. Applications to the cardiovascular, neural, and musculoskeletal systems are highlighted with recent nonclinical studies and clinical trials. The authors also discuss how advances in biomaterials research can contribute to regenerative medicine research and stem cell therapies.

Original languageEnglish (US)
Article number1809009
JournalAdvanced Functional Materials
Volume29
Issue number23
DOIs
StatePublished - Jun 6 2019

Fingerprint

stem cells
Biocompatible Materials
Stem cells
medicine
Biomaterials
Medicine
delivery
engineering
therapy
Tissue
stems
organs
Musculoskeletal system
cardiovascular system
transplantation
Cell death
musculoskeletal system
death
Scaffolds
cells

Keywords

  • biomaterials
  • cardiovascular regeneration
  • musculoskeletal regeneration
  • neural regeneration
  • stem cell delivery

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrochemistry

Cite this

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title = "Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine",
abstract = "Stem cell–based therapies can potentially regenerate many types of tissues and organs, thereby providing solutions to a variety of diseases and injuries. However, acute cell death, uncontrolled differentiation, and low functional engraftment yields remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation, and integration to host tissues may potentially transform the clinical outcome of stem cell–based regenerative therapies. In this review, the authors briefly summarize sources of stem cells for transplantation, present the current state of the art in biomaterial design for stem cell delivery, and provide critical analysis for existing materials. Applications to the cardiovascular, neural, and musculoskeletal systems are highlighted with recent nonclinical studies and clinical trials. The authors also discuss how advances in biomaterials research can contribute to regenerative medicine research and stem cell therapies.",
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Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine. / Wang, Xinlong; Rivera-Bolanos, Nancy; Jiang, Bin; Ameer, Guillermo Antonio.

In: Advanced Functional Materials, Vol. 29, No. 23, 1809009, 06.06.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine

AU - Wang, Xinlong

AU - Rivera-Bolanos, Nancy

AU - Jiang, Bin

AU - Ameer, Guillermo Antonio

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Y1 - 2019/6/6

N2 - Stem cell–based therapies can potentially regenerate many types of tissues and organs, thereby providing solutions to a variety of diseases and injuries. However, acute cell death, uncontrolled differentiation, and low functional engraftment yields remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation, and integration to host tissues may potentially transform the clinical outcome of stem cell–based regenerative therapies. In this review, the authors briefly summarize sources of stem cells for transplantation, present the current state of the art in biomaterial design for stem cell delivery, and provide critical analysis for existing materials. Applications to the cardiovascular, neural, and musculoskeletal systems are highlighted with recent nonclinical studies and clinical trials. The authors also discuss how advances in biomaterials research can contribute to regenerative medicine research and stem cell therapies.

AB - Stem cell–based therapies can potentially regenerate many types of tissues and organs, thereby providing solutions to a variety of diseases and injuries. However, acute cell death, uncontrolled differentiation, and low functional engraftment yields remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation, and integration to host tissues may potentially transform the clinical outcome of stem cell–based regenerative therapies. In this review, the authors briefly summarize sources of stem cells for transplantation, present the current state of the art in biomaterial design for stem cell delivery, and provide critical analysis for existing materials. Applications to the cardiovascular, neural, and musculoskeletal systems are highlighted with recent nonclinical studies and clinical trials. The authors also discuss how advances in biomaterials research can contribute to regenerative medicine research and stem cell therapies.

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KW - musculoskeletal regeneration

KW - neural regeneration

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