Abstract
Objective Lipoproteins are associated with atherogenic and inflammatory processes, and these processes may be related to adverse pregnancy outcomes. We therefore examined whether variations in lipoprotein particle size and concentration are associated with preterm birth (PTB) <35 weeks' gestation. Study Design This is a case-control ancillary study to a randomized trial of omega-3 fatty acid supplementation to prevent recurrent PTB. We measured standard lipids and used nuclear magnetic resonance (NMR) spectroscopy to characterize 17 lipoprotein particles from plasma collected at the baseline randomization visit (16-21 weeks' gestation) in 128 cases (PTB <35 weeks' gestation) and 132 term controls. Logistic regression models controlled for study center, race/ethnicity, number of prior PTB, smoking, and treatment group, as well as total low-density lipoprotein (LDL), high-density lipoprotein, and triglyceride concentrations when examining LDLNMR, high-density lipoproteinNMR, and very LDL (VLDL)NMR, respectively. Results Only 1 of the 17 NMR lipoproteins was associated with recurrent PTB. We observed an increased odds of recurrent PTB of 1.04 (95% confidence interval, 1.01-1.08; P =.02) per nanometer increase in VLDLNMR particle size and an odds ratio of 3.00 (confidence interval, 1.40-6.43; P =.005) for the third tertile of VLDLNMR particle size compared with the first tertile. Conclusion In women with prior PTB, variations in midpregnancy lipoproteins were not associated with recurrent PTB overall, however the association observed with VLDLNMR particle size is suggestive that PTB may be amenable to lifestyle, nutritional, or pharmacologic interventions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 342.e1-342.e7 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 209 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2013 |
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Keywords
- birth
- lipids
- nutrition
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
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Advanced lipoprotein measures and recurrent preterm birth. / Thorp, John M.; Rice, Madeline Murguia; Harper, Margaret; Klebanoff, Mark; Sorokin, Yoram; Varner, Michael W.; Wapner, Ronald J.; Caritis, Steve N.; Iams, Jay D.; Peaceman, Alan M; Mercer, Brian M.; Sciscione, Anthony; Rouse, Dwight J.; Ramin, Susan M.; Anderson, Garland B.
In: American Journal of Obstetrics and Gynecology, Vol. 209, No. 4, 01.01.2013, p. 342.e1-342.e7.Research output: Contribution to journal › Article
TY - JOUR
T1 - Advanced lipoprotein measures and recurrent preterm birth
AU - Thorp, John M.
AU - Rice, Madeline Murguia
AU - Harper, Margaret
AU - Klebanoff, Mark
AU - Sorokin, Yoram
AU - Varner, Michael W.
AU - Wapner, Ronald J.
AU - Caritis, Steve N.
AU - Iams, Jay D.
AU - Peaceman, Alan M
AU - Mercer, Brian M.
AU - Sciscione, Anthony
AU - Rouse, Dwight J.
AU - Ramin, Susan M.
AU - Anderson, Garland B.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Objective Lipoproteins are associated with atherogenic and inflammatory processes, and these processes may be related to adverse pregnancy outcomes. We therefore examined whether variations in lipoprotein particle size and concentration are associated with preterm birth (PTB) <35 weeks' gestation. Study Design This is a case-control ancillary study to a randomized trial of omega-3 fatty acid supplementation to prevent recurrent PTB. We measured standard lipids and used nuclear magnetic resonance (NMR) spectroscopy to characterize 17 lipoprotein particles from plasma collected at the baseline randomization visit (16-21 weeks' gestation) in 128 cases (PTB <35 weeks' gestation) and 132 term controls. Logistic regression models controlled for study center, race/ethnicity, number of prior PTB, smoking, and treatment group, as well as total low-density lipoprotein (LDL), high-density lipoprotein, and triglyceride concentrations when examining LDLNMR, high-density lipoproteinNMR, and very LDL (VLDL)NMR, respectively. Results Only 1 of the 17 NMR lipoproteins was associated with recurrent PTB. We observed an increased odds of recurrent PTB of 1.04 (95% confidence interval, 1.01-1.08; P =.02) per nanometer increase in VLDLNMR particle size and an odds ratio of 3.00 (confidence interval, 1.40-6.43; P =.005) for the third tertile of VLDLNMR particle size compared with the first tertile. Conclusion In women with prior PTB, variations in midpregnancy lipoproteins were not associated with recurrent PTB overall, however the association observed with VLDLNMR particle size is suggestive that PTB may be amenable to lifestyle, nutritional, or pharmacologic interventions.
AB - Objective Lipoproteins are associated with atherogenic and inflammatory processes, and these processes may be related to adverse pregnancy outcomes. We therefore examined whether variations in lipoprotein particle size and concentration are associated with preterm birth (PTB) <35 weeks' gestation. Study Design This is a case-control ancillary study to a randomized trial of omega-3 fatty acid supplementation to prevent recurrent PTB. We measured standard lipids and used nuclear magnetic resonance (NMR) spectroscopy to characterize 17 lipoprotein particles from plasma collected at the baseline randomization visit (16-21 weeks' gestation) in 128 cases (PTB <35 weeks' gestation) and 132 term controls. Logistic regression models controlled for study center, race/ethnicity, number of prior PTB, smoking, and treatment group, as well as total low-density lipoprotein (LDL), high-density lipoprotein, and triglyceride concentrations when examining LDLNMR, high-density lipoproteinNMR, and very LDL (VLDL)NMR, respectively. Results Only 1 of the 17 NMR lipoproteins was associated with recurrent PTB. We observed an increased odds of recurrent PTB of 1.04 (95% confidence interval, 1.01-1.08; P =.02) per nanometer increase in VLDLNMR particle size and an odds ratio of 3.00 (confidence interval, 1.40-6.43; P =.005) for the third tertile of VLDLNMR particle size compared with the first tertile. Conclusion In women with prior PTB, variations in midpregnancy lipoproteins were not associated with recurrent PTB overall, however the association observed with VLDLNMR particle size is suggestive that PTB may be amenable to lifestyle, nutritional, or pharmacologic interventions.
KW - birth
KW - lipids
KW - nutrition
UR - http://www.scopus.com/inward/record.url?scp=84884673649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884673649&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2013.06.005
DO - 10.1016/j.ajog.2013.06.005
M3 - Article
VL - 209
SP - 342.e1-342.e7
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -