Advanced smart-photosensitizers for more effective cancer treatment

Wooram Park; Soojeong Cho; Jieun Han; Heejun Shin; Kun Na; Byeongdu Lee; Dong Hyun Kim

doi:10.1039/c7bm00872d

Advanced smart-photosensitizers for more effective cancer treatment

Wooram Park, Soojeong Cho, Jieun Han, Heejun Shin, Kun Na^*, Byeongdu Lee, Dong Hyun Kim

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

Original language	English (US)
Pages (from-to)	79-90
Number of pages	12
Journal	Biomaterials Science
Volume	6
Issue number	1
DOIs	https://doi.org/10.1039/c7bm00872d
State	Published - Jan 2018

ASJC Scopus subject areas

Biomedical Engineering
Materials Science(all)

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@article{c64b895674154a1d806a200eafac0bd9,

title = "Advanced smart-photosensitizers for more effective cancer treatment",

abstract = "Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.",

author = "Wooram Park and Soojeong Cho and Jieun Han and Heejun Shin and Kun Na and Byeongdu Lee and Kim, {Dong Hyun}",

note = "Funding Information: The financial support from the NIH/NIBIB and NIH/NCI for R21CA173491 (D.-H. K.), R21CA185274 (D.-H. K.), and R21EB017986 (D.-H. K.) is greatly acknowledged. This work was also supported by the National Research Foundation of Korea (NRF) (NRF-2017R1A2B3010038 and 2015R1A4A1042350). BL is supported by the DOE Office of Science through the Argonne National Laboratory under Contract No. DE-AC02-06CH11357.",

year = "2018",

month = jan,

doi = "10.1039/c7bm00872d",

language = "English (US)",

volume = "6",

pages = "79--90",

journal = "Biomaterials Science",

issn = "2047-4830",

publisher = "Royal Society of Chemistry",

number = "1",

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T1 - Advanced smart-photosensitizers for more effective cancer treatment

AU - Park, Wooram

AU - Cho, Soojeong

AU - Han, Jieun

AU - Shin, Heejun

AU - Na, Kun

AU - Lee, Byeongdu

AU - Kim, Dong Hyun

N1 - Funding Information: The financial support from the NIH/NIBIB and NIH/NCI for R21CA173491 (D.-H. K.), R21CA185274 (D.-H. K.), and R21EB017986 (D.-H. K.) is greatly acknowledged. This work was also supported by the National Research Foundation of Korea (NRF) (NRF-2017R1A2B3010038 and 2015R1A4A1042350). BL is supported by the DOE Office of Science through the Argonne National Laboratory under Contract No. DE-AC02-06CH11357.

PY - 2018/1

Y1 - 2018/1

N2 - Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

AB - Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

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