Advanced smart-photosensitizers for more effective cancer treatment

Wooram Park, Soojeong Cho, Jieun Han, Heejun Shin, Kun Na*, Byeongdu Lee, Dong Hyun Kim

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

Original languageEnglish (US)
Pages (from-to)79-90
Number of pages12
JournalBiomaterials Science
Volume6
Issue number1
DOIs
StatePublished - Jan 2018

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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