Advances in adjuvant therapy of gastrointestinal stromal tumors

Kehinde Adekola, Mark Agulnik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The Gastrointestinal Stromal Tumor (GIST) is the most common sarcoma of the gastrointestinal tract. Major prognostic indices in the evaluation and management of GIST include the size, location and tumor mitotic rate. The discovery of the mutation in the tyrosine kinase receptor c-KIT (CD117) revolutionized the treatment of GIST in the early twenty-first century. Since the first case report of the success of the tyrosine kinase inhibitor (TKI) imatinib, in the treatment of a female patient with metastatic GIST, the paradigm of treatment of this tumor has evolved tremendously. The initial use in metastatic GISTs has progressed to use of the TKI in both the adjuvant and neoadjuvant settings. It is now standard of care for patients with complete resection of primary localized GIST, with high risk of recurrence, to have at least one year of adjuvant imatinib. Recent SSGVXIII study shows that patients benefit from extended duration of therapy.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalCurrent oncology reports
Volume14
Issue number4
DOIs
StatePublished - Aug 1 2012

Keywords

  • Gastrointestinal stromal tumor
  • Imatinib
  • Tyrosine Kinase Inhibitors

ASJC Scopus subject areas

  • Oncology

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