Advances in functional neurosurgery for Parkinson's disease

Leo Verhagen Metman*, Konstantin V. Slavin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Functional neurosurgery for Parkinson's disease has become a mainstream concept with DBS as the prime modality. This article reviews the latest and, in the eyes of the authors, the most important developments in DBS, lesioning and gene therapy. In DBS, emerging advances have focused on the timing of surgery relative to disease duration and severity, and new targets, technologies, and equipment. For lesions, new ultrasound techniques are emerging based on successes in other movement disorders. Gene and cellular therapies, including stem cells, remain only in the research realm.

Original languageEnglish (US)
Pages (from-to)1461-1470
Number of pages10
JournalMovement Disorders
Issue number11
StatePublished - Sep 15 2015


  • Closed loop
  • Current steering
  • DBS
  • Focused ultrasound
  • Frameless
  • Functional neurosurgery
  • Gene therapy
  • Intra-operative CT
  • Intra-operative MRI
  • Parkinson
  • Surgery

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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