Abstract
Purpose of Review: Advanced liver disease is a leading cause of non-AIDS-related morbidity and mortality in persons with HIV on antiretroviral therapy. As a result, persons with HIV are increasingly seeking liver transplantation. Recent Findings: With the availability of direct-acting antiviral hepatitis C therapies, there has been a shift in the indications for liver transplantation in persons with HIV, with non-alcoholic fatty liver disease now the leading indication over hepatitis C infection. Additionally, liver transplant outcomes have improved in persons with HIV-hepatitis C co-infection persons with HIV. Preliminary results of HIV-to-HIV liver transplantation show acceptable results although rates of post-transplant infections and malignancies are areas of concern. Summary: Future studies of liver transplantation in persons with HIV should focus on long-term outcomes, especially in the context of steatohepatitis and co-existing morbidities like diabetes, hyperlipidemia, and cardiovascular disease and other prevalent diseases in an aging population.
Original language | English (US) |
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Pages (from-to) | 39-50 |
Number of pages | 12 |
Journal | Current Infectious Disease Reports |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2022 |
Keywords
- Hepatitis B virus
- Hepatitis C virus
- Human immunodeficiency virus
- Liver disease
- Liver transplantation
- Non-alcoholic fatty liver disease
ASJC Scopus subject areas
- Infectious Diseases