Advances in Liver Transplantation for Persons with Human Immunodeficiency Infection

Rebecca N. Kumar, Valentina Stosor*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Advanced liver disease is a leading cause of non-AIDS-related morbidity and mortality in persons with HIV on antiretroviral therapy. As a result, persons with HIV are increasingly seeking liver transplantation. Recent Findings: With the availability of direct-acting antiviral hepatitis C therapies, there has been a shift in the indications for liver transplantation in persons with HIV, with non-alcoholic fatty liver disease now the leading indication over hepatitis C infection. Additionally, liver transplant outcomes have improved in persons with HIV-hepatitis C co-infection persons with HIV. Preliminary results of HIV-to-HIV liver transplantation show acceptable results although rates of post-transplant infections and malignancies are areas of concern. Summary: Future studies of liver transplantation in persons with HIV should focus on long-term outcomes, especially in the context of steatohepatitis and co-existing morbidities like diabetes, hyperlipidemia, and cardiovascular disease and other prevalent diseases in an aging population.

Original languageEnglish (US)
Pages (from-to)39-50
Number of pages12
JournalCurrent Infectious Disease Reports
Volume24
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • Hepatitis B virus
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Liver disease
  • Liver transplantation
  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Infectious Diseases

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