Advances in localized surface plasmon resonance spectroscopy biosensing

Laura B. Sagle; Laura K. Ruvuna; Julia A. Ruemmele; Richard P. Van Duyne

doi:10.2217/nnm.11.117

Advances in localized surface plasmon resonance spectroscopy biosensing

Laura B. Sagle, Laura K. Ruvuna, Julia A. Ruemmele, Richard P. Van Duyne^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

142 Scopus citations

Abstract

In recent years, localized surface plasmon resonance (LSPR) spectroscopy advancements have made it a sensitive, flexible tool for probing biological interactions. Here, we describe the basic principles of this nanoparticle-based sensing technique, the ways nanoparticles can be tailored to optimize sensing, and examples of novel LSPR spectroscopy applications. These include detecting small molecules via protein conformational changes and resonance LSPR spectroscopy, as well as coupling LSPR with mass spectrometry to identify bound analytes. The last few sections highlight the advantages of single nanoparticle LSPR, in that it lowers limits of detection, allows multiplexing on the nanometer scale, and enables free diffusion of sensors in solution. The cases discussed herein illustrate creative ways that LSPR spectroscopy has been improved to achieve new sensing capabilities.

Original language	English (US)
Pages (from-to)	1447-1462
Number of pages	16
Journal	Nanomedicine
Volume	6
Issue number	8
DOIs	https://doi.org/10.2217/nnm.11.117
State	Published - Oct 2011

Keywords

LSPR
biosensing
imaging
multiplex
nanoparticle
tracking

ASJC Scopus subject areas

Bioengineering
General Materials Science
Biomedical Engineering
Medicine (miscellaneous)

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10.2217/nnm.11.117

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abstract = "In recent years, localized surface plasmon resonance (LSPR) spectroscopy advancements have made it a sensitive, flexible tool for probing biological interactions. Here, we describe the basic principles of this nanoparticle-based sensing technique, the ways nanoparticles can be tailored to optimize sensing, and examples of novel LSPR spectroscopy applications. These include detecting small molecules via protein conformational changes and resonance LSPR spectroscopy, as well as coupling LSPR with mass spectrometry to identify bound analytes. The last few sections highlight the advantages of single nanoparticle LSPR, in that it lowers limits of detection, allows multiplexing on the nanometer scale, and enables free diffusion of sensors in solution. The cases discussed herein illustrate creative ways that LSPR spectroscopy has been improved to achieve new sensing capabilities.",

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AB - In recent years, localized surface plasmon resonance (LSPR) spectroscopy advancements have made it a sensitive, flexible tool for probing biological interactions. Here, we describe the basic principles of this nanoparticle-based sensing technique, the ways nanoparticles can be tailored to optimize sensing, and examples of novel LSPR spectroscopy applications. These include detecting small molecules via protein conformational changes and resonance LSPR spectroscopy, as well as coupling LSPR with mass spectrometry to identify bound analytes. The last few sections highlight the advantages of single nanoparticle LSPR, in that it lowers limits of detection, allows multiplexing on the nanometer scale, and enables free diffusion of sensors in solution. The cases discussed herein illustrate creative ways that LSPR spectroscopy has been improved to achieve new sensing capabilities.

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Advances in localized surface plasmon resonance spectroscopy biosensing

Abstract

Keywords

ASJC Scopus subject areas

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