Advances in mechanisms of asthma, allergy, and immunology in 2011

Joshua A. Boyce*, Bruce Bochner, Fred D. Finkelman, Marc E. Rothenberg

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T H 17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume129
Issue number2
DOIs
StatePublished - Jan 1 2012

Keywords

  • Galactose-α-1,3-galactose
  • Toll-like receptor
  • calcitonin gene-related peptide
  • cyclic AMP
  • dendritic cell
  • facilitated antigen binding
  • facilitated antigen presentation
  • genome-wide association study
  • interferon
  • lipopolysaccharide
  • toluidine diisothiocyanate
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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