Abstract
Globally, a rising burden of complex diseases takes a heavy toll on human lives and poses substantial clinical and economic challenges. This review covers nanomedicine and nanotechnology-enabled advanced drug delivery systems (DDS) designed to address various unmet medical needs. Key nanomedicine and DDSs, currently employed in the clinic to tackle some of these diseases, are discussed focusing on their versatility in diagnostics, anticancer therapy, and diabetes management. First-hand experiences from our own laboratory and the work of others are presented to provide insights into strategies to design and optimize nanomedicine- and nanotechnology-enabled DDS for enhancing therapeutic outcomes. Computational analysis is also briefly reviewed as a technology for rational design of controlled release DDS. Further explorations of DDS have illuminated the interplay of physiological barriers and their impact on DDS. It is demonstrated how such delivery systems can overcome these barriers for enhanced therapeutic efficacy and how new perspectives of next-generation DDS can be applied clinically.
Original language | English (US) |
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Pages (from-to) | 1722-1765 |
Number of pages | 44 |
Journal | Molecular Pharmaceutics |
Volume | 19 |
Issue number | 6 |
DOIs | |
State | Published - Jun 6 2022 |
Funding
This work is supported in part by the Weston Brain Institute Transformational Grant, University of Toronto Connaught Innovation Award, Killam Research Fellowship by the Canada Council for the Arts, Project Grants from the Canadian Institutes of Health Research, Discovery and Equipment Grants from the Natural Sciences and Engineering Research Council of Canada, JDRF International, and Hemsley Charitable Trust Grants to X.Y.W. The authors also acknowledge the University of Toronto Connaught International Scholarship for Doctoral Students and the Pfizer Canada Graduate Fellowship in Pharmaceutical Sciences to T.A., the Centre for Collaborative Drug Research Graduate Student Incentive Fund to X.Y.W., the Ontario Graduate Scholarship (OGS) to B.L. and T.Z., the Queen Elizabeth Award to B.L. and H.Y.L., the Pharmaceutical Sciences Graduate Student Association Fellowship to E.P., King Abdulaziz City for Science and Technology (KACST) for the scholarship to I.A., Libyan Ministry of Higher Education scholarship to A.Z., Mitacs Accelerate Intership to F.J.L., the BBDC Seller Fellowship to A.GN., and the Mitacs Accelerate Fellowship to K.C.
Keywords
- blood-brain barrier (BBB)-penetrating
- multitargeted drug delivery
- nanomedicine
- polymer lipid hybrid nanoparticles (PLN)
- stimulus-responsive drug release
- synergistic drug combination
- tumor microenvironment modulation
ASJC Scopus subject areas
- Drug Discovery
- Molecular Medicine
- Pharmaceutical Science