Advances in Nanomedicine Design: Multidisciplinary Strategies for Unmet Medical Needs

Taksim Ahmed, Fuh Ching Franky Liu, Brian Lu, Hoyin Lip, Elliya Park, Ibrahim Alradwan, Jackie Fule Liu, Chunsheng He, Abdulmottaleb Zetrini, Tian Zhang, Amin Ghavaminejad, Andrew M. Rauth, Jeffrey T. Henderson, Xiao Yu Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Globally, a rising burden of complex diseases takes a heavy toll on human lives and poses substantial clinical and economic challenges. This review covers nanomedicine and nanotechnology-enabled advanced drug delivery systems (DDS) designed to address various unmet medical needs. Key nanomedicine and DDSs, currently employed in the clinic to tackle some of these diseases, are discussed focusing on their versatility in diagnostics, anticancer therapy, and diabetes management. First-hand experiences from our own laboratory and the work of others are presented to provide insights into strategies to design and optimize nanomedicine- and nanotechnology-enabled DDS for enhancing therapeutic outcomes. Computational analysis is also briefly reviewed as a technology for rational design of controlled release DDS. Further explorations of DDS have illuminated the interplay of physiological barriers and their impact on DDS. It is demonstrated how such delivery systems can overcome these barriers for enhanced therapeutic efficacy and how new perspectives of next-generation DDS can be applied clinically.

Original languageEnglish (US)
Pages (from-to)1722-1765
Number of pages44
JournalMolecular Pharmaceutics
Issue number6
StatePublished - Jun 6 2022


  • blood-brain barrier (BBB)-penetrating
  • multitargeted drug delivery
  • nanomedicine
  • polymer lipid hybrid nanoparticles (PLN)
  • stimulus-responsive drug release
  • synergistic drug combination
  • tumor microenvironment modulation

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Pharmaceutical Science


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