Advances in serous tubal intraepithelial carcinoma: Correlation with high grade serous carcinoma and ovarian carcinogenesis

Hong Xia Li, Zhao Hui Lu, Keng Shen, Wen Jun Cheng, Anais Malpica, Jing Zhang, Jian Jun Wei, Zhi Hong Zhang, Jinsong Liu*

*Corresponding author for this work

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Early serous carcinoma in fallopian tube or serous tubal intraepithelial carcinoma (STIC), an early lesion limited to the epithelium of the fallopian tube and firstly identified from specimen obtained by prophylactic salpingo-oophorectomy, has provided insight into pelvic high grade serous carcinoma (HGSC). Increasing evidence indicates that STIC is a likely precursor for HGSC and several studies have focused on this lesion and its clinical significance. This review addresses recent advances in recognizing STIC and its correlation with HGSC and ovarian carcinogenesis. It also describes evidence regarding the fallopian tube as a source of some HGSCs, the protocol for optimizing histological evaluation of the tubes, the spectrum of tubal lesions from benign to noninvasive carcinoma, changes in diagnostic criteria from purely morphologic characteristics to a combination of morphologic features and molecular biomarkers, and new studies about potential biomarkers. However, the direct evidence regarding STIC as the precursor of HGSC is still tantalizing due to other possibilities that may also explain the origin of pelvic HGSC. Further molecular genetic studies are required to address this important question.

Original languageEnglish (US)
Pages (from-to)848-857
Number of pages10
JournalInternational Journal of Clinical and Experimental Pathology
Volume7
Issue number3
StatePublished - 2014

Keywords

  • Carcinogenesis
  • Fallopian tube
  • High grade serous carcinoma
  • Ovarian cancer
  • Serous tubal intraepithelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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