Advances in studying phasic dopamine signaling in brain reward mechanisms

Robert J. Wickham, Wojciech Solecki, Liza R. Rathbun, Nichole M. Neugebauer, Robert Mark Wightman, Nii A. Addy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The last sixty years of research has provided extraordinary advances of our knowledge of the reward system. Since its discovery as a neurotransmitter by Carlsson and colleagues (1), dopamine (DA) has emerged as an important mediator of reward processing. As a result, a number of electrochemical techniques have been developed to measure DA in the brain. Together, these techniques have begun to elucidate the complex roles of tonic and phasic DA signaling in reward processing and addiction. In this review, we will first provide a guide for the most commonly used electrochemical methods for DA detection and describe their utility in furthering our knowledge about DA's role in reward and addiction. Second, we will review the value of common in vitro and in vivo preparations and describe their ability to address different types of questions. Last, we will review recent data that has provided new mechanistic insight of in vivo phasic DA signaling and its role in reward processing and reward-mediated behavior.

Original languageEnglish (US)
Pages (from-to)982-999
Number of pages18
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number3
StatePublished - Jun 1 2013


  • Dopamine
  • Psychostimulant
  • Reinforcement learning
  • Review
  • Rewardrelated behavior
  • Striatum
  • Voltammetry

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


Dive into the research topics of 'Advances in studying phasic dopamine signaling in brain reward mechanisms'. Together they form a unique fingerprint.

Cite this