Adverse birth outcome across the generations: the contribution of paternal factors

Zoe Tullius*, Kristin Rankin, Carla DeSisto, James W. Collins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: There is literature suggesting an intergenerational relationship between maternal and infant size for gestational age status and preterm birth, but much less is known about the contribution of paternal birth outcome to infant birth outcome. This study seeks to determine the association between paternal and infant small-for-gestational-age status (weight for gestational age ' 10th percentile, SGA) and preterm birth (' 37 weeks gestation, PTB) in a large, diverse population-based sample in the United States. Methods: Stratified and log-binomial multivariable regression analyses were computed on the vital records of Illinois-born infants (1989–1991) and their Illinois-born parents (born 1956–1976). Results: Among non-Hispanic Whites (n = 83,218), the adjusted (controlling for maternal SGA or PTB, age, parity, education, marital status, prenatal care, and cigarette smoking) relative risk (95% confidence interval) of infant SGA and PTB for former SGA (compared to non-SGA) and preterm (compared to term) fathers equaled 1.65 (1.53, 1.77) and 1.07 (0.92, 1.24), respectively. Among African-Americans (n = 8401), the adjusted relative risk (95% confidence interval) of infant SGA and PTB for former SGA (compared to non-SGA) and preterm (compared to term) fathers equaled 1.32 (1.14, 1.52) and 1.19 (0.98, 1.45), respectively. Conclusion: Paternal adverse birth outcome, particularly SGA, is a modest risk factor for corresponding adverse infant outcome, independent of maternal risk status. This phenomenon appears to occur similarly among non-Hispanic White and African-American women.

Original languageEnglish (US)
Pages (from-to)1151-1157
Number of pages7
JournalArchives of Gynecology and Obstetrics
Volume302
Issue number5
DOIs
StatePublished - Nov 1 2020
Externally publishedYes

Keywords

  • Paternal preterm birth
  • Paternal small for gestational age
  • Preterm birth
  • Small for gestational age

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Adverse birth outcome across the generations: the contribution of paternal factors'. Together they form a unique fingerprint.

Cite this