Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos

Kaitlyn K. Stanhope; Alison L. Cammack; Krista M. Perreira; Lindsay Fernández-Rhodes; Christina Cordero; Linda C. Gallo; Carmen R. Isasi; Sheila F. Castañeda; Martha L. Daviglus; Michelle A. Kominiarek; Shakira S. Suglia

doi:10.1016/j.annepidem.2020.08.004

Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos

Kaitlyn K. Stanhope^*, Alison L. Cammack, Krista M. Perreira, Lindsay Fernández-Rhodes, Christina Cordero, Linda C. Gallo, Carmen R. Isasi, Sheila F. Castañeda, Martha L. Daviglus, Michelle A. Kominiarek, Shakira S. Suglia

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Purpose: Childhood adversity is associated with increased risk of adult disease, including type II diabetes and hypertension. However, little is known about potential associations between childhood adversity and adverse pregnancy outcomes. The goal of this study was to examine the relationship between adverse childhood experiences (ACEs) and ever experiencing gestational diabetes mellitus (GDM) or a hypertensive disorder of pregnancy (HDP) in a cohort of Hispanic or Latina women. Methods: We analyzed data from 2319 women from the Hispanic Community Health Study/Study of Latinos who had ever given birth to a liveborn infant. We fit separate logistic regression models accounting for sample weights to examine the association between ACEs and risk of GDM and HDP adjusting for Hispanic/Latino background, age at immigration to the United States, and education. Results: Women who reported four or more ACEs did not show increased odds of GDM or HDP compared with those who reported three or fewer (GDM adjusted odds ratio: 0.8 [0.5, 1.3]; HDP adjusted OR: 1.0 [0.7, 1.5]). Conclusions: Unlike previous research with majority non-Hispanic White cohorts, there was no association between ACEs and GDM or HDP. Future research should explore if this relationship varies by race/ethnicity in multiethnic cohorts.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Annals of Epidemiology
Volume	50
DOIs	https://doi.org/10.1016/j.annepidem.2020.08.004
State	Published - Oct 2020

Funding

The authors thank the staff and participants of HCHS/SOL for their important contributions. Investigators website—http://www.cscc.unc.edu/hchs/. The Hispanic Community Health Study/Study of Latinos is a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (HHSN268201300001I/N01-HC-65233), University of Miami (HHSN268201300004I/N01-HC-65234), Albert Einstein College of Medicine (HHSN268201300002I/N01-HC 65235), University of Illinois at Chicago–HHSN268201300003I/N01-HC-65236 Northwestern Univ), and San Diego State University (HHSN268201300005I/N01-HC-65237). The following Institutes/Centers/Offices have contributed to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, and NIH Institution-Office of Dietary Supplements. Conflict of interest: All authors have participated in (a) conception and design, or analysis and interpretation of the data; (b) drafting the article or revising it critically for important intellectual content; and (c) approval of the final version. This manuscript has not been submitted to, nor is under review at, another journal or other publishing venue. The authors have no affiliation with any organization with a direct or indirect financial interest in the subject matter discussed in the manuscript, Authors’ contributions: K.K.S. contributed to conceptualization, methodology, formal analysis, and writing the original article. A.LC. contributed to reviewing and editing the article and methodology. K.M.P. contributed to reviewing and editing the article, investigation, and resources. L.F.-R. contributed to reviewing and editing the article, investigation, and resources. C.C. contributed to reviewing and editing the article. L.C.G. contributed to reviewing and editing the article, investigation, and resources. C.R.I. contributed to reviewing and editing the article, investigation, and resources. S.F.C. contributed to reviewing and editing the article. M.LD. contributed to reviewing and editing the article, investigation, and resources. M.A.K. contributed to reviewing and editing the article. S.F.S. contributed to reviewing and editing, conceptualization, and supervision.

Keywords

Childhood adversity
Gestational diabetes
Hypertensive disorders of pregnancy

ASJC Scopus subject areas

Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.annepidem.2020.08.004

Cite this

Stanhope, K. K., Cammack, A. L., Perreira, K. M., Fernández-Rhodes, L., Cordero, C., Gallo, L. C., Isasi, C. R., Castañeda, S. F., Daviglus, M. L., Kominiarek, M. A., & Suglia, S. S. (2020). Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos. Annals of Epidemiology, 50, 1-6. https://doi.org/10.1016/j.annepidem.2020.08.004

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title = "Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos",

abstract = "Purpose: Childhood adversity is associated with increased risk of adult disease, including type II diabetes and hypertension. However, little is known about potential associations between childhood adversity and adverse pregnancy outcomes. The goal of this study was to examine the relationship between adverse childhood experiences (ACEs) and ever experiencing gestational diabetes mellitus (GDM) or a hypertensive disorder of pregnancy (HDP) in a cohort of Hispanic or Latina women. Methods: We analyzed data from 2319 women from the Hispanic Community Health Study/Study of Latinos who had ever given birth to a liveborn infant. We fit separate logistic regression models accounting for sample weights to examine the association between ACEs and risk of GDM and HDP adjusting for Hispanic/Latino background, age at immigration to the United States, and education. Results: Women who reported four or more ACEs did not show increased odds of GDM or HDP compared with those who reported three or fewer (GDM adjusted odds ratio: 0.8 [0.5, 1.3]; HDP adjusted OR: 1.0 [0.7, 1.5]). Conclusions: Unlike previous research with majority non-Hispanic White cohorts, there was no association between ACEs and GDM or HDP. Future research should explore if this relationship varies by race/ethnicity in multiethnic cohorts.",

keywords = "Childhood adversity, Gestational diabetes, Hypertensive disorders of pregnancy",

author = "Stanhope, {Kaitlyn K.} and Cammack, {Alison L.} and Perreira, {Krista M.} and Lindsay Fern{\'a}ndez-Rhodes and Christina Cordero and Gallo, {Linda C.} and Isasi, {Carmen R.} and Casta{\~n}eda, {Sheila F.} and Daviglus, {Martha L.} and Kominiarek, {Michelle A.} and Suglia, {Shakira S.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = oct,

doi = "10.1016/j.annepidem.2020.08.004",

language = "English (US)",

volume = "50",

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Stanhope, KK, Cammack, AL, Perreira, KM, Fernández-Rhodes, L, Cordero, C, Gallo, LC, Isasi, CR, Castañeda, SF, Daviglus, ML, Kominiarek, MA & Suglia, SS 2020, 'Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos', Annals of Epidemiology, vol. 50, pp. 1-6. https://doi.org/10.1016/j.annepidem.2020.08.004

Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos. / Stanhope, Kaitlyn K.; Cammack, Alison L.; Perreira, Krista M. et al.
In: Annals of Epidemiology, Vol. 50, 10.2020, p. 1-6.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos

AU - Stanhope, Kaitlyn K.

AU - Cammack, Alison L.

AU - Perreira, Krista M.

AU - Fernández-Rhodes, Lindsay

AU - Cordero, Christina

AU - Gallo, Linda C.

AU - Isasi, Carmen R.

AU - Castañeda, Sheila F.

AU - Daviglus, Martha L.

AU - Kominiarek, Michelle A.

AU - Suglia, Shakira S.

PY - 2020/10

Y1 - 2020/10

N2 - Purpose: Childhood adversity is associated with increased risk of adult disease, including type II diabetes and hypertension. However, little is known about potential associations between childhood adversity and adverse pregnancy outcomes. The goal of this study was to examine the relationship between adverse childhood experiences (ACEs) and ever experiencing gestational diabetes mellitus (GDM) or a hypertensive disorder of pregnancy (HDP) in a cohort of Hispanic or Latina women. Methods: We analyzed data from 2319 women from the Hispanic Community Health Study/Study of Latinos who had ever given birth to a liveborn infant. We fit separate logistic regression models accounting for sample weights to examine the association between ACEs and risk of GDM and HDP adjusting for Hispanic/Latino background, age at immigration to the United States, and education. Results: Women who reported four or more ACEs did not show increased odds of GDM or HDP compared with those who reported three or fewer (GDM adjusted odds ratio: 0.8 [0.5, 1.3]; HDP adjusted OR: 1.0 [0.7, 1.5]). Conclusions: Unlike previous research with majority non-Hispanic White cohorts, there was no association between ACEs and GDM or HDP. Future research should explore if this relationship varies by race/ethnicity in multiethnic cohorts.

AB - Purpose: Childhood adversity is associated with increased risk of adult disease, including type II diabetes and hypertension. However, little is known about potential associations between childhood adversity and adverse pregnancy outcomes. The goal of this study was to examine the relationship between adverse childhood experiences (ACEs) and ever experiencing gestational diabetes mellitus (GDM) or a hypertensive disorder of pregnancy (HDP) in a cohort of Hispanic or Latina women. Methods: We analyzed data from 2319 women from the Hispanic Community Health Study/Study of Latinos who had ever given birth to a liveborn infant. We fit separate logistic regression models accounting for sample weights to examine the association between ACEs and risk of GDM and HDP adjusting for Hispanic/Latino background, age at immigration to the United States, and education. Results: Women who reported four or more ACEs did not show increased odds of GDM or HDP compared with those who reported three or fewer (GDM adjusted odds ratio: 0.8 [0.5, 1.3]; HDP adjusted OR: 1.0 [0.7, 1.5]). Conclusions: Unlike previous research with majority non-Hispanic White cohorts, there was no association between ACEs and GDM or HDP. Future research should explore if this relationship varies by race/ethnicity in multiethnic cohorts.

KW - Childhood adversity

KW - Gestational diabetes

KW - Hypertensive disorders of pregnancy

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SN - 1047-2797

VL - 50

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JO - Annals of Epidemiology

JF - Annals of Epidemiology

ER -

Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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