The ω-conopeptide, ziconotide, is an N-type calcium-channel blocker that has been shown to produce antinociception in animals using formalin and hot-plate tests. Initial reports of intrathecal administration of ziconotide in cancer and AIDS patients whose pain was unrelieved with opioids demonstrated analgesic efficacy. Although adverse effects were reported, these appeared to be easily managed through dose reduction or symptomatic treatment. This clinical report describes the experiences of three patients with serious adverse effects associated with intrathecal ziconotide. (C) 2000 International Association for the Study of Pain.
- N-type calcium-channel blocker
- Neuropathic pain
- Side effects
ASJC Scopus subject areas
- Clinical Neurology
- Anesthesiology and Pain Medicine