Adverse effects of chronic cardiac denervation in conscious dogs with myocardial ischemia

M. Lavallee, J. Amano, S. F. Vatner, W. T. Manders, W. C. Randall, J. X. Thomas

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The extent to which total chronic cardiac denervation protects the ischemic myocardium was investigated in conscious dogs. The major hemodynamic difference after coronary artery occlusion was that left ventricular end-diastolic pressure rose significantly more, P < 0.01, in the denervated group (12 ± 1.5 mm Hg) than in the normal group (4.4 ± 1.4 mm Hg). Blood flow (radioactive microspheres) in the ischemic endo- and epicardium fell to similar levels at 3-5 minutes after coronary occlusion, but was significantly less (P < 0.01) in denervated dogs at 3 hours after occlusion in the endo- (0.05 ± 0.01) and epicardium (0.30 ± 0.02 ml/min per g), than in the endo- (0.13 ± 0.03) and epicardium (0.42 ± 0.05 ml/min per g) in the normal group. A subgroup of normal dogs was also studied, with left ventricular end-diastolic pressure increased by volume loading to levels similar to those observed in the denervated group after coronary occlusion; in these dogs, blood flow was similar to that in the other two groups 3-5 minutes after coronary artery occlusion, but, at 3 hours, was significantly more depressed (P < 0.01) than that observed in normal dogs without volume loading in both endo- (0.03 ± 0.01) and epicardial (0.25 ± 0.03 ml/min per g) layers. Infarct size, as a fraction of the area at risk, was significantly greater (P < 0.05) in the denervated group (60 ± 4.3%) and in the subgroup of normal dogs with elevated left ventricular end-diastolic pressure (73 ± 5.8%), compared with the normal group without volume loading (37 ± 8.1%). Thus, in conscious dogs, total chronic cardiac denervation exerts an adverse effect on infarct size which may be related to the sustained elevation in left ventricular end-diastolic pressure and consequent impairment of collateral perfusion.

Original languageEnglish (US)
Pages (from-to)383-392
Number of pages10
JournalCirculation research
Volume57
Issue number3
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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