TY - JOUR
T1 - Adverse events during hematopoietic stem cell infusion
T2 - Analysis of the infusion product
AU - Vidula, Neelima
AU - Villa, Marcelo
AU - Helenowski, Irene B.
AU - Merchant, Mehboob
AU - Jovanovic, Borko D.
AU - Meagher, Richard
AU - Mehta, Jayesh
AU - Singhal, Seema
AU - Winter, Jane N.
AU - Frankfurt, Olga
AU - Altman, Jessica K.
AU - Williams, Stephanie F.
AU - Gordon, Leo I.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/11
Y1 - 2015/11
N2 - Background Stem cell transplantation is a treatment option for patients with cancer. However, a risk of adverse events might be associated with the infusion itself. An understanding of the types and grades of adverse events occurring during infusion and the patient and infusion characteristics that might be associated with these events could allow for interventions to minimize these complications. The risk factors associated with transplant-related adverse events are not well understood. Materials and Methods We retrospectively analyzed the adverse events occurring within 1 hour after infusion in 460 patients with cancer undergoing stem cell transplantation at the Northwestern University Robert H. Lurie Comprehensive Cancer Center from January 1, 2008 and May 1, 2011. Of the 460 patients, 382 received autologous transplants and 78 allogeneic transplants. The incidence, types, and National Cancer Institute Common Terminology Criteria grade of toxicity for adverse events were noted (primary objective). Univariate analyses were performed to study which patient and infusion characteristics might be associated with the occurrence of adverse events (secondary objectives). Results Of the 460 patients, 261 (56.7%) experienced adverse events (66.7% during allogeneic infusion and 54.7% during autologous infusion). Most events were cardiopulmonary. Univariate analysis of the infusion and patient characteristics revealed that a second transplant (P =.005) was associated with more adverse events for autologous transplant patients. For allogeneic transplant patients, a higher infusion red blood cell volume (P =.01) was associated with more adverse events. Conclusion Adverse events are common during stem cell infusion and are generally cardiopulmonary.
AB - Background Stem cell transplantation is a treatment option for patients with cancer. However, a risk of adverse events might be associated with the infusion itself. An understanding of the types and grades of adverse events occurring during infusion and the patient and infusion characteristics that might be associated with these events could allow for interventions to minimize these complications. The risk factors associated with transplant-related adverse events are not well understood. Materials and Methods We retrospectively analyzed the adverse events occurring within 1 hour after infusion in 460 patients with cancer undergoing stem cell transplantation at the Northwestern University Robert H. Lurie Comprehensive Cancer Center from January 1, 2008 and May 1, 2011. Of the 460 patients, 382 received autologous transplants and 78 allogeneic transplants. The incidence, types, and National Cancer Institute Common Terminology Criteria grade of toxicity for adverse events were noted (primary objective). Univariate analyses were performed to study which patient and infusion characteristics might be associated with the occurrence of adverse events (secondary objectives). Results Of the 460 patients, 261 (56.7%) experienced adverse events (66.7% during allogeneic infusion and 54.7% during autologous infusion). Most events were cardiopulmonary. Univariate analysis of the infusion and patient characteristics revealed that a second transplant (P =.005) was associated with more adverse events for autologous transplant patients. For allogeneic transplant patients, a higher infusion red blood cell volume (P =.01) was associated with more adverse events. Conclusion Adverse events are common during stem cell infusion and are generally cardiopulmonary.
KW - Allogeneic transplantation
KW - Autologous transplantation
KW - Cardiopulmonary adverse events
KW - Infusion red blood cell volume
KW - Second transplant
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U2 - 10.1016/j.clml.2015.08.085
DO - 10.1016/j.clml.2015.08.085
M3 - Article
C2 - 26482109
AN - SCOPUS:84946827527
SN - 2152-2650
VL - 15
SP - e157-e162
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 11
ER -