Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus

Pin Lin, Elisa Rhew, Roberta B. Ness, Alan M Peaceman, Alan Richard Dyer, David McPherson, George T. Kondos, Daniel Edmundowicz, Kim Sutton-Tyrrell, Trina Thompson, Rosalind Ramsey-Goldman*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/objective: Patients with systemic lupus erythematosus (SLE) are at increased risk for adverse pregnancy outcomes and cardiovascular disease (CVD). The objective of this exploratory study was to investigate the association between a history of adverse pregnancy outcomes and subsequent risk of subclinical CVD assessed by imaging studies and verified clinical CVD events in 129 women with SLE. Methods: The occurrence of adverse pregnancy outcomes, specifically pre-eclampsia, preterm birth and low birth weight was ascertained by questionnaire. Subclinical CVD was assessed by coronary artery calcium (CAC) as measured by electron beam CT and carotid plaque measured by B mode ultrasound. Clinical CVD events were verified by medical record review. Logistic regression was used to estimate the association of pregnancy complications with occurrence of subclinical CVD and clinical CVD with a priori adjustment for age, which is associated with CVD and SLE disease duration as a measure of SLE disease burden. Results: Fifty-six women reported at least one pregnancy complication while 73 had none. Twenty-six women had at least one pregnancy complicated by preeclampsia and were more likely to have a CAC score greater than or equal to 10 (adjusted OR=3.7; 95% CI 1.2 to 11.9), but the presence of plaque was not associated with this pregnancy complication, OR=1.1, (95% CI 0.4 to 2.8). Low birth weight and preterm birth were not associated with CAC or plaque. Conclusions: Patients with SLE with a history of preeclampsia had a higher rate of subclinical CVD as measured by CAC score. Future studies are needed to confirm the relationship between adverse pregnancy outcomes and subsequent subclinical CVD and clinical CVD events.

Original languageEnglish (US)
Article numbere000024
JournalLupus Science and Medicine
Volume1
Issue number1
DOIs
StatePublished - Jun 1 2014

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Pregnancy Outcome
Systemic Lupus Erythematosus
Cardiovascular Diseases
Pregnancy Complications
Coronary Vessels
Pre-Eclampsia
Calcium
Premature Birth
Low Birth Weight Infant
Medical Records
Logistic Models
Electrons
Pregnancy

ASJC Scopus subject areas

  • Immunology

Cite this

Lin, Pin ; Rhew, Elisa ; Ness, Roberta B. ; Peaceman, Alan M ; Dyer, Alan Richard ; McPherson, David ; Kondos, George T. ; Edmundowicz, Daniel ; Sutton-Tyrrell, Kim ; Thompson, Trina ; Ramsey-Goldman, Rosalind. / Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus. In: Lupus Science and Medicine. 2014 ; Vol. 1, No. 1.
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title = "Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus",
abstract = "Background/objective: Patients with systemic lupus erythematosus (SLE) are at increased risk for adverse pregnancy outcomes and cardiovascular disease (CVD). The objective of this exploratory study was to investigate the association between a history of adverse pregnancy outcomes and subsequent risk of subclinical CVD assessed by imaging studies and verified clinical CVD events in 129 women with SLE. Methods: The occurrence of adverse pregnancy outcomes, specifically pre-eclampsia, preterm birth and low birth weight was ascertained by questionnaire. Subclinical CVD was assessed by coronary artery calcium (CAC) as measured by electron beam CT and carotid plaque measured by B mode ultrasound. Clinical CVD events were verified by medical record review. Logistic regression was used to estimate the association of pregnancy complications with occurrence of subclinical CVD and clinical CVD with a priori adjustment for age, which is associated with CVD and SLE disease duration as a measure of SLE disease burden. Results: Fifty-six women reported at least one pregnancy complication while 73 had none. Twenty-six women had at least one pregnancy complicated by preeclampsia and were more likely to have a CAC score greater than or equal to 10 (adjusted OR=3.7; 95{\%} CI 1.2 to 11.9), but the presence of plaque was not associated with this pregnancy complication, OR=1.1, (95{\%} CI 0.4 to 2.8). Low birth weight and preterm birth were not associated with CAC or plaque. Conclusions: Patients with SLE with a history of preeclampsia had a higher rate of subclinical CVD as measured by CAC score. Future studies are needed to confirm the relationship between adverse pregnancy outcomes and subsequent subclinical CVD and clinical CVD events.",
author = "Pin Lin and Elisa Rhew and Ness, {Roberta B.} and Peaceman, {Alan M} and Dyer, {Alan Richard} and David McPherson and Kondos, {George T.} and Daniel Edmundowicz and Kim Sutton-Tyrrell and Trina Thompson and Rosalind Ramsey-Goldman",
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Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus. / Lin, Pin; Rhew, Elisa; Ness, Roberta B.; Peaceman, Alan M; Dyer, Alan Richard; McPherson, David; Kondos, George T.; Edmundowicz, Daniel; Sutton-Tyrrell, Kim; Thompson, Trina; Ramsey-Goldman, Rosalind.

In: Lupus Science and Medicine, Vol. 1, No. 1, e000024, 01.06.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus

AU - Lin, Pin

AU - Rhew, Elisa

AU - Ness, Roberta B.

AU - Peaceman, Alan M

AU - Dyer, Alan Richard

AU - McPherson, David

AU - Kondos, George T.

AU - Edmundowicz, Daniel

AU - Sutton-Tyrrell, Kim

AU - Thompson, Trina

AU - Ramsey-Goldman, Rosalind

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Background/objective: Patients with systemic lupus erythematosus (SLE) are at increased risk for adverse pregnancy outcomes and cardiovascular disease (CVD). The objective of this exploratory study was to investigate the association between a history of adverse pregnancy outcomes and subsequent risk of subclinical CVD assessed by imaging studies and verified clinical CVD events in 129 women with SLE. Methods: The occurrence of adverse pregnancy outcomes, specifically pre-eclampsia, preterm birth and low birth weight was ascertained by questionnaire. Subclinical CVD was assessed by coronary artery calcium (CAC) as measured by electron beam CT and carotid plaque measured by B mode ultrasound. Clinical CVD events were verified by medical record review. Logistic regression was used to estimate the association of pregnancy complications with occurrence of subclinical CVD and clinical CVD with a priori adjustment for age, which is associated with CVD and SLE disease duration as a measure of SLE disease burden. Results: Fifty-six women reported at least one pregnancy complication while 73 had none. Twenty-six women had at least one pregnancy complicated by preeclampsia and were more likely to have a CAC score greater than or equal to 10 (adjusted OR=3.7; 95% CI 1.2 to 11.9), but the presence of plaque was not associated with this pregnancy complication, OR=1.1, (95% CI 0.4 to 2.8). Low birth weight and preterm birth were not associated with CAC or plaque. Conclusions: Patients with SLE with a history of preeclampsia had a higher rate of subclinical CVD as measured by CAC score. Future studies are needed to confirm the relationship between adverse pregnancy outcomes and subsequent subclinical CVD and clinical CVD events.

AB - Background/objective: Patients with systemic lupus erythematosus (SLE) are at increased risk for adverse pregnancy outcomes and cardiovascular disease (CVD). The objective of this exploratory study was to investigate the association between a history of adverse pregnancy outcomes and subsequent risk of subclinical CVD assessed by imaging studies and verified clinical CVD events in 129 women with SLE. Methods: The occurrence of adverse pregnancy outcomes, specifically pre-eclampsia, preterm birth and low birth weight was ascertained by questionnaire. Subclinical CVD was assessed by coronary artery calcium (CAC) as measured by electron beam CT and carotid plaque measured by B mode ultrasound. Clinical CVD events were verified by medical record review. Logistic regression was used to estimate the association of pregnancy complications with occurrence of subclinical CVD and clinical CVD with a priori adjustment for age, which is associated with CVD and SLE disease duration as a measure of SLE disease burden. Results: Fifty-six women reported at least one pregnancy complication while 73 had none. Twenty-six women had at least one pregnancy complicated by preeclampsia and were more likely to have a CAC score greater than or equal to 10 (adjusted OR=3.7; 95% CI 1.2 to 11.9), but the presence of plaque was not associated with this pregnancy complication, OR=1.1, (95% CI 0.4 to 2.8). Low birth weight and preterm birth were not associated with CAC or plaque. Conclusions: Patients with SLE with a history of preeclampsia had a higher rate of subclinical CVD as measured by CAC score. Future studies are needed to confirm the relationship between adverse pregnancy outcomes and subsequent subclinical CVD and clinical CVD events.

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DO - 10.1136/lupus-2014-000024

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