Abstract
Dapsone is used in prophylaxis for and treatment of Pneumocystis carinii pneumonia. We present a case of Stevens-Johnson syndrome that was likely induced by administration of dapsone. A review of charts at the HIV Treatment Center of Northwestern University (Chicago) revealed that 40.3% of patients treated with trimethoprim-sulfamethoxazole could not tolerate the medication, while 25.2% of those treated with dapsone were intolerant of the drug. We also found a higher rate of adverse reactions to dapsone among patients with prior intolerance to trimethoprim-sulfamethoxazole than among patients without such a history; however, the difference was not significant.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 630-632 |
| Number of pages | 3 |
| Journal | Clinical Infectious Diseases |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1994 |
Funding
Received 10 May 1993; revised 3 August 1993. Dr. Pertel was supported by a research fellowship from the Howard Hughes Medical Institute. Chevy Chase. Maryland. Reprints or correspondence: Dr. Peter Pertel, Division ofInfectious Diseases. Northwestern University Medical School, 303 East Superior. Room 828. Chicago. Illinois 60611.
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
