Adverse reactions to dapsone in persons infected with human immunodeficiency virus

Peter Pertel*, Robert Hirschtick

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Dapsone is used in prophylaxis for and treatment of Pneumocystis carinii pneumonia. We present a case of Stevens-Johnson syndrome that was likely induced by administration of dapsone. A review of charts at the HIV Treatment Center of Northwestern University (Chicago) revealed that 40.3% of patients treated with trimethoprim-sulfamethoxazole could not tolerate the medication, while 25.2% of those treated with dapsone were intolerant of the drug. We also found a higher rate of adverse reactions to dapsone among patients with prior intolerance to trimethoprim-sulfamethoxazole than among patients without such a history; however, the difference was not significant.

Original languageEnglish (US)
Pages (from-to)630-632
Number of pages3
JournalClinical Infectious Diseases
Volume18
Issue number4
DOIs
StatePublished - Apr 1994

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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