Adverse reactions to radiographic contrast material

Leslie C. Grammer*, Roy Patterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Adverse reactions are common in patients who receive radiographic contrast media (RCM) for diagnostic procedures. The agents used are iodinated, aromatic compounds that are administered as a salt with varying amounts of sodium or methylglucamine. The incidence of such adverse reactions, according to various sources in the literature,1-4 varies from 5% to 8%. These adverse reactions are anaphylactoid in l-2%.3-6 The incidence of fatality appears to be about 1:40,000,7 although various studies have reported mortality rates as high as 1:10,0001 and as low as 1:116,000.8 Types of adverse reactions to RCM vary and the etiologies are unclear; thus, the approaches to prevention and treatment require an understanding of the diversity. It is useful to classify adverse RCM reactions into one of four types-chemotoxic, hemodynamic, vagal, or anaphylactoid-each of which has different clinical manifestations. Very importantly, the underlying physiology and the appropriate therapeutic and preventive interventions also vary. Anaphylactoid reactions are the most serious adverse RCM reactions.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalClinics in Dermatology
Issue number1
StatePublished - 1986

ASJC Scopus subject areas

  • Dermatology


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