Affect processing and positive syndrome schizotypy in cannabis users

Patrick D. Skosnik*, Sohee Park, Laura Dobbs, Wendi L. Gardner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


While cannabis is associated with positive syndrome schizophrenia (SZ), it is unclear whether cannabinoids are also related to negative symptoms such as affective blunting. We examined whether cannabis use is associated with schizotypy and utilized event-related potentials (ERPs) to assess affect processing. Cannabis users demonstrated increased P300 amplitudes for unpleasant trait words, and demonstrated higher positive syndrome schizotypy which correlated with levels of cannabis use. The cannabis group also exhibited lower negative syndrome schizotypy. The lack of blunted responses during the affect ERP and decreased negative subscale schizotypy scores provide evidence that the endocannabinoid theory of schizophrenia may be primarily relevant in relation to positive syndrome SZ.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalPsychiatry Research
Issue number1-3
StatePublished - Jan 15 2008


  • Event-related potentials
  • Marijuana
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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