Age-dependent differences in t-cell responses to influenza a virus

Andrew D. Prigge*, Ruihua Ma, Bria M. Coates, Benjamin D. Singer, Karen M. Ridge

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Respiratory infections from influenza A virus (IAV) cause substantial morbidity and mortality in children relative to adults. T cells play a critical role in the host response to IAV by supporting the innate and humoral responses,mediating cytotoxic activity, and promoting recovery. There are age-dependent differences in the number, subsets, and localization of T cells, which impact the host response to pathogens. In this article, we first review how T cells recognize IAV and examine differences in the resting T-cell populations between juveniles and adults. Next, we describe how the juvenile CD4+, CD8+, and regulatory T-cell responses compare with those in adults and discuss the potential physiologic and clinical consequences of the differences. Finally, we explore the roles of two unconventional T-cell types in the juvenile response to influenza, natural-killer T cells and γδ T cells. A clear understanding of age-dependent differences in the T-cell response is essential to developing therapies to prevent or reverse the deleterious effects of IAV in children.

Original languageEnglish (US)
Pages (from-to)415-423
Number of pages9
JournalAmerican journal of respiratory cell and molecular biology
Volume63
Issue number4
DOIs
StatePublished - Oct 2020

Keywords

  • Agedependent
  • Influenza
  • Juvenile
  • T cell
  • Viral pneumonia

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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