Age Differences by Sex in Antiretroviral-Naïve Participants: Pooled Analysis from Randomized Clinical Trials

La Ree A. Tracy, Kimberly Struble, Cynthia Firnhaber, Laura Smeaton, Jordan E. Lake, Tanvir Bell, Guoxing (Gregg) Soon, Jin Yan, Kathryn Schnippel, Susan E. Cohn

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Age and sex effects on antiretroviral therapy (ART) response are not well elucidated. Our pooled analysis of 40 randomized clinical trials measured the association of age and sex on CD4+ T cell count changes and virologic suppression using multivariable regression modeling. The average increase in CD4+ T cell count from baseline to week 48 was 17.3 cells/mm 3 lower and clinically insignificant (95% confidence interval −30.8 to −3.8) among women ages ≥ 50 years (n = 573), compared to women ≤ 35 years (n = 3,939). Results were similar for men. Virologic suppression odds were 60% and 21% times greater among participants ≥50 years compared to ≤35 years, in women and men, respectively. In both sexes, larger increases in CD4+ T cell count changes were observed in younger, compared to older, participants; however, virologic suppression was higher in older, compared to younger, participants suggesting a non-sex-specific age effect response to ART.

Original languageEnglish (US)
Pages (from-to)371-382
Number of pages12
JournalJournal of the Association of Nurses in AIDS Care
Volume29
Issue number3
DOIs
StatePublished - May 1 2018

Keywords

  • HIV
  • age
  • menopause
  • pooled analysis
  • response to antiretroviral therapy
  • women

ASJC Scopus subject areas

  • Advanced and Specialized Nursing

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