@article{78316844e5e04d6c84b3250cf3b1eeac,
title = "Age Differences by Sex in Antiretroviral-Na{\"i}ve Participants: Pooled Analysis from Randomized Clinical Trials",
abstract = " Age and sex effects on antiretroviral therapy (ART) response are not well elucidated. Our pooled analysis of 40 randomized clinical trials measured the association of age and sex on CD4+ T cell count changes and virologic suppression using multivariable regression modeling. The average increase in CD4+ T cell count from baseline to week 48 was 17.3 cells/mm 3 lower and clinically insignificant (95% confidence interval −30.8 to −3.8) among women ages ≥ 50 years (n = 573), compared to women ≤ 35 years (n = 3,939). Results were similar for men. Virologic suppression odds were 60% and 21% times greater among participants ≥50 years compared to ≤35 years, in women and men, respectively. In both sexes, larger increases in CD4+ T cell count changes were observed in younger, compared to older, participants; however, virologic suppression was higher in older, compared to younger, participants suggesting a non-sex-specific age effect response to ART. ",
keywords = "HIV, age, menopause, pooled analysis, response to antiretroviral therapy, women",
author = "Tracy, {La Ree A.} and Kimberly Struble and Cynthia Firnhaber and Laura Smeaton and Lake, {Jordan E.} and Tanvir Bell and Soon, {Guoxing (Gregg)} and Jin Yan and Kathryn Schnippel and Cohn, {Susan E.}",
note = "Funding Information: Grant funding: Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases under Award Numbers AI068636 (Principal Investigator [PI]: Daniel Kuritzkes), UM1AI068634 (PI: Michael Hughes), UM1AI106701 (PI: Robert Coombs), UM1U01AI69471 (PI: Babafemi Taiwo), 5UM1AI069463 (PI: Ian Sanne), UM1AI069424 (PI: Judith Currier), and UM1AI069503-10 (PI: Fred Gordin). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. This project was supported in part by an appointment to the ORISE Research Participation Program at the Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA), administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and FDA/CDER and by the FDA Office of Women's Health and FDA CDER Critical Path Program. Publisher Copyright: {\textcopyright} 2018",
year = "2018",
month = may,
day = "1",
doi = "10.1016/j.jana.2018.01.004",
language = "English (US)",
volume = "29",
pages = "371--382",
journal = "Journal of the Association of Nurses in AIDS Care",
issn = "1055-3290",
publisher = "Elsevier USA",
number = "3",
}
