Age influences the emm type distribution of pediatric group A streptococcal pharyngeal isolates

Preeti Jaggi*, Robert R Tanz, Bernard Beall, Stanford T Shulman

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: emm types 12, 1, 28, 3, 4, 2 and 6 (in that order) are the types most commonly associated with uncomplicated group A streptococcal (GAS) pharyngitis in the United States, together accounting for ∼78% of isolates. Objective: To determine whether the distribution of common pharyngeal group A streptococcal GAS types differs at various ages throughout childhood. Study Design: We emm typed 3356 GAS isolates collected from the United States and Canada during 3 streptococcal seasons (2000-2003). Variations in prevalence by age for the 7 most prevalent emm types and the "uncommon" category (all types accounting for <5% of the total number of isolates) were analyzed and assessed for significance by χ2. Results: The proportion of uncommon isolates increased significantly with increasing age from 18% in group 1 to 37% in group 4 (P = 0.001). We found a significant decrease in the proportion of the common pharyngeal emm types, specifically emm 12 and emm 4 type isolates, with increasing age (P = 0.001 and P = 0.003, respectively); there was no significant decline in the prevalence of other common pharyngeal types (emm 1, 2, 3, 6 and 28) with increasing age. Conclusion: Age-related changes in emm type distribution of pharyngeal GAS are present in childhood; these changes may reflect acquisition of immunity to more common types as a consequence of exposure early in life, but this remains to be demonstrated.

Original languageEnglish (US)
Pages (from-to)1089-1092
Number of pages4
JournalPediatric Infectious Disease Journal
Volume24
Issue number12
DOIs
StatePublished - Jan 1 2005

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Pediatrics
Pharyngitis
Canada
Immunity

Keywords

  • Children
  • M type
  • Streptococcus pyogenes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Age influences the emm type distribution of pediatric group A streptococcal pharyngeal isolates",
abstract = "Background: emm types 12, 1, 28, 3, 4, 2 and 6 (in that order) are the types most commonly associated with uncomplicated group A streptococcal (GAS) pharyngitis in the United States, together accounting for ∼78{\%} of isolates. Objective: To determine whether the distribution of common pharyngeal group A streptococcal GAS types differs at various ages throughout childhood. Study Design: We emm typed 3356 GAS isolates collected from the United States and Canada during 3 streptococcal seasons (2000-2003). Variations in prevalence by age for the 7 most prevalent emm types and the {"}uncommon{"} category (all types accounting for <5{\%} of the total number of isolates) were analyzed and assessed for significance by χ2. Results: The proportion of uncommon isolates increased significantly with increasing age from 18{\%} in group 1 to 37{\%} in group 4 (P = 0.001). We found a significant decrease in the proportion of the common pharyngeal emm types, specifically emm 12 and emm 4 type isolates, with increasing age (P = 0.001 and P = 0.003, respectively); there was no significant decline in the prevalence of other common pharyngeal types (emm 1, 2, 3, 6 and 28) with increasing age. Conclusion: Age-related changes in emm type distribution of pharyngeal GAS are present in childhood; these changes may reflect acquisition of immunity to more common types as a consequence of exposure early in life, but this remains to be demonstrated.",
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Age influences the emm type distribution of pediatric group A streptococcal pharyngeal isolates. / Jaggi, Preeti; Tanz, Robert R; Beall, Bernard; Shulman, Stanford T.

In: Pediatric Infectious Disease Journal, Vol. 24, No. 12, 01.01.2005, p. 1089-1092.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age influences the emm type distribution of pediatric group A streptococcal pharyngeal isolates

AU - Jaggi, Preeti

AU - Tanz, Robert R

AU - Beall, Bernard

AU - Shulman, Stanford T

PY - 2005/1/1

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N2 - Background: emm types 12, 1, 28, 3, 4, 2 and 6 (in that order) are the types most commonly associated with uncomplicated group A streptococcal (GAS) pharyngitis in the United States, together accounting for ∼78% of isolates. Objective: To determine whether the distribution of common pharyngeal group A streptococcal GAS types differs at various ages throughout childhood. Study Design: We emm typed 3356 GAS isolates collected from the United States and Canada during 3 streptococcal seasons (2000-2003). Variations in prevalence by age for the 7 most prevalent emm types and the "uncommon" category (all types accounting for <5% of the total number of isolates) were analyzed and assessed for significance by χ2. Results: The proportion of uncommon isolates increased significantly with increasing age from 18% in group 1 to 37% in group 4 (P = 0.001). We found a significant decrease in the proportion of the common pharyngeal emm types, specifically emm 12 and emm 4 type isolates, with increasing age (P = 0.001 and P = 0.003, respectively); there was no significant decline in the prevalence of other common pharyngeal types (emm 1, 2, 3, 6 and 28) with increasing age. Conclusion: Age-related changes in emm type distribution of pharyngeal GAS are present in childhood; these changes may reflect acquisition of immunity to more common types as a consequence of exposure early in life, but this remains to be demonstrated.

AB - Background: emm types 12, 1, 28, 3, 4, 2 and 6 (in that order) are the types most commonly associated with uncomplicated group A streptococcal (GAS) pharyngitis in the United States, together accounting for ∼78% of isolates. Objective: To determine whether the distribution of common pharyngeal group A streptococcal GAS types differs at various ages throughout childhood. Study Design: We emm typed 3356 GAS isolates collected from the United States and Canada during 3 streptococcal seasons (2000-2003). Variations in prevalence by age for the 7 most prevalent emm types and the "uncommon" category (all types accounting for <5% of the total number of isolates) were analyzed and assessed for significance by χ2. Results: The proportion of uncommon isolates increased significantly with increasing age from 18% in group 1 to 37% in group 4 (P = 0.001). We found a significant decrease in the proportion of the common pharyngeal emm types, specifically emm 12 and emm 4 type isolates, with increasing age (P = 0.001 and P = 0.003, respectively); there was no significant decline in the prevalence of other common pharyngeal types (emm 1, 2, 3, 6 and 28) with increasing age. Conclusion: Age-related changes in emm type distribution of pharyngeal GAS are present in childhood; these changes may reflect acquisition of immunity to more common types as a consequence of exposure early in life, but this remains to be demonstrated.

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