Age-related changes in aortic 3D blood flow velocities and wall shear stress: Implications for the identification of altered hemodynamics in patients with aortic valve disease

Pim Van Ooij*, Julio Garcia, Wouter V. Potters, S Chris Malaisrie, Jeremy D Collins, James Carr, Michael Markl, Alex J Barker

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose To investigate age-related changes in peak systolic aortic 3D velocity and wall shear stress (WSS) in healthy controls and to investigate the importance of age-matching for 3D mapping of abnormal aortic hemodynamics in bicuspid aortic valve disease (BAV). Materials and Methods 4D flow MRI (fields strengths = 1.5-3T; resolution = 2.2-3.9 × 1.7-2.6 × 2.2-4.0 mm3; Venc = 150-250 cm/s; TE/TR/FA = 2.3-2.8/4.7-5.4msec/7-15°) was performed in 56 controls (age range: 19-78 years) and in two BAV patient groups each consisting of 10 subjects (group 1: 20-29 years, group 2: 52-57 years). Heat maps showing abnormal 3D velocity and WSS were created for the BAV patients by comparison with an age-matched and with an unmatched control group. The fraction of the aorta exposed to abnormal velocity/WSS was calculated relative to the total aortic volume/surface. Results Significant inverse relationships between age and healthy velocity/WSS were found (R2 = 0.32/0.39, P < 0.001). For BAV group 1, abnormally elevated velocity/WSS was overestimated when compared with older controls (51-60 years) than when correctly age-matched (∼25 ± 14% vs. ∼8 ± 5%). For BAV group 2, abnormally decreased velocity/WSS was overestimated when compared with younger controls (21-30 years) than when correctly age-matched (∼9 ± 7% vs. 1 ± 1%). Conclusion Significant correlations exist between age and peak systolic velocity and WSS. Therefore, robust age-matching is important when creating abnormal 3D aortic velocity and WSS maps for patients with BAV.

Original languageEnglish (US)
Pages (from-to)1239-1249
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume43
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Aortic Diseases
Blood Flow Velocity
Aortic Valve
Hemodynamics
Aorta
Bicuspid Aortic Valve
Hot Temperature
Control Groups

Keywords

  • 4D flow MRI
  • bicuspid valve disease
  • healthy controls
  • wall shear stress

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{fd527fc05f0e4dc5ab73cf5f1bede5f9,
title = "Age-related changes in aortic 3D blood flow velocities and wall shear stress: Implications for the identification of altered hemodynamics in patients with aortic valve disease",
abstract = "Purpose To investigate age-related changes in peak systolic aortic 3D velocity and wall shear stress (WSS) in healthy controls and to investigate the importance of age-matching for 3D mapping of abnormal aortic hemodynamics in bicuspid aortic valve disease (BAV). Materials and Methods 4D flow MRI (fields strengths = 1.5-3T; resolution = 2.2-3.9 × 1.7-2.6 × 2.2-4.0 mm3; Venc = 150-250 cm/s; TE/TR/FA = 2.3-2.8/4.7-5.4msec/7-15°) was performed in 56 controls (age range: 19-78 years) and in two BAV patient groups each consisting of 10 subjects (group 1: 20-29 years, group 2: 52-57 years). Heat maps showing abnormal 3D velocity and WSS were created for the BAV patients by comparison with an age-matched and with an unmatched control group. The fraction of the aorta exposed to abnormal velocity/WSS was calculated relative to the total aortic volume/surface. Results Significant inverse relationships between age and healthy velocity/WSS were found (R2 = 0.32/0.39, P < 0.001). For BAV group 1, abnormally elevated velocity/WSS was overestimated when compared with older controls (51-60 years) than when correctly age-matched (∼25 ± 14{\%} vs. ∼8 ± 5{\%}). For BAV group 2, abnormally decreased velocity/WSS was overestimated when compared with younger controls (21-30 years) than when correctly age-matched (∼9 ± 7{\%} vs. 1 ± 1{\%}). Conclusion Significant correlations exist between age and peak systolic velocity and WSS. Therefore, robust age-matching is important when creating abnormal 3D aortic velocity and WSS maps for patients with BAV.",
keywords = "4D flow MRI, bicuspid valve disease, healthy controls, wall shear stress",
author = "{Van Ooij}, Pim and Julio Garcia and Potters, {Wouter V.} and Malaisrie, {S Chris} and Collins, {Jeremy D} and James Carr and Michael Markl and Barker, {Alex J}",
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Age-related changes in aortic 3D blood flow velocities and wall shear stress : Implications for the identification of altered hemodynamics in patients with aortic valve disease. / Van Ooij, Pim; Garcia, Julio; Potters, Wouter V.; Malaisrie, S Chris; Collins, Jeremy D; Carr, James; Markl, Michael; Barker, Alex J.

In: Journal of Magnetic Resonance Imaging, Vol. 43, No. 5, 01.05.2016, p. 1239-1249.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-related changes in aortic 3D blood flow velocities and wall shear stress

T2 - Implications for the identification of altered hemodynamics in patients with aortic valve disease

AU - Van Ooij, Pim

AU - Garcia, Julio

AU - Potters, Wouter V.

AU - Malaisrie, S Chris

AU - Collins, Jeremy D

AU - Carr, James

AU - Markl, Michael

AU - Barker, Alex J

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Purpose To investigate age-related changes in peak systolic aortic 3D velocity and wall shear stress (WSS) in healthy controls and to investigate the importance of age-matching for 3D mapping of abnormal aortic hemodynamics in bicuspid aortic valve disease (BAV). Materials and Methods 4D flow MRI (fields strengths = 1.5-3T; resolution = 2.2-3.9 × 1.7-2.6 × 2.2-4.0 mm3; Venc = 150-250 cm/s; TE/TR/FA = 2.3-2.8/4.7-5.4msec/7-15°) was performed in 56 controls (age range: 19-78 years) and in two BAV patient groups each consisting of 10 subjects (group 1: 20-29 years, group 2: 52-57 years). Heat maps showing abnormal 3D velocity and WSS were created for the BAV patients by comparison with an age-matched and with an unmatched control group. The fraction of the aorta exposed to abnormal velocity/WSS was calculated relative to the total aortic volume/surface. Results Significant inverse relationships between age and healthy velocity/WSS were found (R2 = 0.32/0.39, P < 0.001). For BAV group 1, abnormally elevated velocity/WSS was overestimated when compared with older controls (51-60 years) than when correctly age-matched (∼25 ± 14% vs. ∼8 ± 5%). For BAV group 2, abnormally decreased velocity/WSS was overestimated when compared with younger controls (21-30 years) than when correctly age-matched (∼9 ± 7% vs. 1 ± 1%). Conclusion Significant correlations exist between age and peak systolic velocity and WSS. Therefore, robust age-matching is important when creating abnormal 3D aortic velocity and WSS maps for patients with BAV.

AB - Purpose To investigate age-related changes in peak systolic aortic 3D velocity and wall shear stress (WSS) in healthy controls and to investigate the importance of age-matching for 3D mapping of abnormal aortic hemodynamics in bicuspid aortic valve disease (BAV). Materials and Methods 4D flow MRI (fields strengths = 1.5-3T; resolution = 2.2-3.9 × 1.7-2.6 × 2.2-4.0 mm3; Venc = 150-250 cm/s; TE/TR/FA = 2.3-2.8/4.7-5.4msec/7-15°) was performed in 56 controls (age range: 19-78 years) and in two BAV patient groups each consisting of 10 subjects (group 1: 20-29 years, group 2: 52-57 years). Heat maps showing abnormal 3D velocity and WSS were created for the BAV patients by comparison with an age-matched and with an unmatched control group. The fraction of the aorta exposed to abnormal velocity/WSS was calculated relative to the total aortic volume/surface. Results Significant inverse relationships between age and healthy velocity/WSS were found (R2 = 0.32/0.39, P < 0.001). For BAV group 1, abnormally elevated velocity/WSS was overestimated when compared with older controls (51-60 years) than when correctly age-matched (∼25 ± 14% vs. ∼8 ± 5%). For BAV group 2, abnormally decreased velocity/WSS was overestimated when compared with younger controls (21-30 years) than when correctly age-matched (∼9 ± 7% vs. 1 ± 1%). Conclusion Significant correlations exist between age and peak systolic velocity and WSS. Therefore, robust age-matching is important when creating abnormal 3D aortic velocity and WSS maps for patients with BAV.

KW - 4D flow MRI

KW - bicuspid valve disease

KW - healthy controls

KW - wall shear stress

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