TY - JOUR
T1 - Age-related decline in peripheral vascular health predicts cognitive impairment
AU - Csipo, Tamas
AU - Lipecz, Agnes
AU - Fulop, Gabor A.
AU - Hand, Rachel A.
AU - Ngo, Bich Thy N.
AU - Dzialendzik, Mikita
AU - Tarantini, Stefano
AU - Balasubramanian, Priya
AU - Kiss, Tamas
AU - Yabluchanska, Valeriya
AU - Silva-Palacios, Federico
AU - Courtney, Donald L.
AU - Dasari, Tarun W.
AU - Sorond, Farzaneh
AU - Sonntag, William E.
AU - Csiszar, Anna
AU - Ungvari, Zoltan
AU - Yabluchanskiy, Andriy
N1 - Funding Information:
Funding information This work was supported by grants from the American Heart Association (ST, ZU, and AC), the Oklahoma Center for the Advancement of Science and Technology (to AC, AY, ZU), the National Center for Complementary and Alternative Medicine (R01-AT006526 to ZU), the National Institute on Aging (R01-AG055395, R01-AG047879; R01-AG038747), the National Institute of Neurological Disorders and Stroke (NINDS; R01-NS100782, R01-NS056218), the Oklahoma Shared Clinical and Translational Resources (OSCTR) program funded by the National Institute of General Medical Sciences (U54GM104938, to AY), the Presbyterian Health Foundation (to ZU, AC, AY), and the EU-funded Hungarian grant EFOP-3.6.1-16-2016-00008. The authors was supported by the NIA/NIH-funded Geroscience Training Program in Oklahoma (T32AG052363) and the Cellular and Molecular GeroScience CoBRE (1P20GM125528, sub#5337).
Publisher Copyright:
© 2019, American Aging Association.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Preclinical studies demonstrate that generalized endothelial cell dysfunction and microvascular impairment are potentially reversible causes of age-related vascular cognitive impairment and dementia (VCID). The present study was designed to test the hypothesis that severity of age-related macro- and microvascular dysfunction measured in the peripheral circulation is an independent predictor of cognitive performance in older adults. In this study, we enrolled 63 healthy individuals into young (< 45 years old) and aged (> 65 years old) groups. We used principal component analysis (PCA) to construct a comprehensive peripheral vascular health index (VHI) encompassing peripheral microvascular reactivity, arterial endothelial function, and vascular stiffness, as a marker of aging-induced generalized vascular dysfunction. Peripheral macrovascular and microvascular endothelial function were assessed using flow-mediated dilation (FMD) and laser speckle contrast imaging tests. Pulse waveform analysis was used to evaluate the augmentation index (AIx), a measure of arterial stiffness. Cognitive function was measured using a panel of CANTAB cognitive tests, and PCA was then applied to generate a cognitive impairment index (CII) for each participant. Aged subjects exhibited significantly impaired macrovascular endothelial function (FMD, 5.6 ± 0.7% vs. 8.3 ± 0.6% in young, p = 0.0061), increased arterial stiffness (AIx 29.3 ± 1.8% vs 4.5 ± 2.6% in young, p < 0.0001), and microvascular dysfunction (2.8 ± 0.2 vs 3.4 ± 0.1-fold change of perfusion in young, p = 0.032). VHI showed a significant negative correlation with age (r = − 0.54, p < 0.0001) and CII significantly correlated with age (r = 0.79, p < 0.0001). VHI significantly correlated with the CII (r = − 0.46, p = 0.0003). A decline in peripheral vascular health may reflect generalized vascular dysfunction and predict cognitive impairment in older adults.
AB - Preclinical studies demonstrate that generalized endothelial cell dysfunction and microvascular impairment are potentially reversible causes of age-related vascular cognitive impairment and dementia (VCID). The present study was designed to test the hypothesis that severity of age-related macro- and microvascular dysfunction measured in the peripheral circulation is an independent predictor of cognitive performance in older adults. In this study, we enrolled 63 healthy individuals into young (< 45 years old) and aged (> 65 years old) groups. We used principal component analysis (PCA) to construct a comprehensive peripheral vascular health index (VHI) encompassing peripheral microvascular reactivity, arterial endothelial function, and vascular stiffness, as a marker of aging-induced generalized vascular dysfunction. Peripheral macrovascular and microvascular endothelial function were assessed using flow-mediated dilation (FMD) and laser speckle contrast imaging tests. Pulse waveform analysis was used to evaluate the augmentation index (AIx), a measure of arterial stiffness. Cognitive function was measured using a panel of CANTAB cognitive tests, and PCA was then applied to generate a cognitive impairment index (CII) for each participant. Aged subjects exhibited significantly impaired macrovascular endothelial function (FMD, 5.6 ± 0.7% vs. 8.3 ± 0.6% in young, p = 0.0061), increased arterial stiffness (AIx 29.3 ± 1.8% vs 4.5 ± 2.6% in young, p < 0.0001), and microvascular dysfunction (2.8 ± 0.2 vs 3.4 ± 0.1-fold change of perfusion in young, p = 0.032). VHI showed a significant negative correlation with age (r = − 0.54, p < 0.0001) and CII significantly correlated with age (r = 0.79, p < 0.0001). VHI significantly correlated with the CII (r = − 0.46, p = 0.0003). A decline in peripheral vascular health may reflect generalized vascular dysfunction and predict cognitive impairment in older adults.
KW - Aging
KW - Cognitive impairment
KW - Endothelial function
KW - Microvascular dysfunction
KW - VCID
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UR - http://www.scopus.com/inward/citedby.url?scp=85066471327&partnerID=8YFLogxK
U2 - 10.1007/s11357-019-00063-5
DO - 10.1007/s11357-019-00063-5
M3 - Article
C2 - 31030329
AN - SCOPUS:85066471327
VL - 41
SP - 125
EP - 136
JO - GeroScience
JF - GeroScience
SN - 2509-2715
IS - 2
ER -