TY - JOUR
T1 - Age-related differences in disease characteristics and clinical outcomes in polycythemia vera
AU - Stein, Brady L.
AU - Saraf, Santosh
AU - Sobol, Urszula
AU - Halpern, Anna
AU - Shammo, Jamile
AU - Rondelli, Damiano
AU - Michaelis, Laura
AU - Odenike, Olatoyosi
AU - Rademaker, Alfred
AU - Zakarija, Anaadriana
AU - McMahon, Brandon J
AU - Spivak, Jerry L.
AU - Moliterno, Alison R.
PY - 2013/9
Y1 - 2013/9
N2 - The natural history and prognosis for young patients with polycythemia vera (PV) in the post-JAK2 V617F era are not well defined. Therefore, we retrospectively analyzed disease characteristics and clinical outcomes in 120 patients ≤ 45 years and 84 patients ≥ 65 years at diagnosis. Despite lower white blood counts (9.2 vs. 13.4 × 109/L, p = 0.004) and a lower JAK2 V617F allele burden (51% vs. 66%, p = 0.015), younger patients with PV had comparable rates of vascular complications compared to older patients (27% vs. 31%, p = 0.64). However, splanchnic vein thrombosis occurred more frequently in younger patients (13% vs. 2%, p = 0.0056). Myelofibrotic and leukemic transformation, the most serious complications of myeloproliferative neoplasms (MPN), occurred with similar frequencies in young versus older patients (15% vs. 10%, p = 0.29). Prevention or delay of these complications is currently the most urgent challenge in the care of younger patients with PV.
AB - The natural history and prognosis for young patients with polycythemia vera (PV) in the post-JAK2 V617F era are not well defined. Therefore, we retrospectively analyzed disease characteristics and clinical outcomes in 120 patients ≤ 45 years and 84 patients ≥ 65 years at diagnosis. Despite lower white blood counts (9.2 vs. 13.4 × 109/L, p = 0.004) and a lower JAK2 V617F allele burden (51% vs. 66%, p = 0.015), younger patients with PV had comparable rates of vascular complications compared to older patients (27% vs. 31%, p = 0.64). However, splanchnic vein thrombosis occurred more frequently in younger patients (13% vs. 2%, p = 0.0056). Myelofibrotic and leukemic transformation, the most serious complications of myeloproliferative neoplasms (MPN), occurred with similar frequencies in young versus older patients (15% vs. 10%, p = 0.29). Prevention or delay of these complications is currently the most urgent challenge in the care of younger patients with PV.
KW - JAK2 V617F
KW - Myeloproliferative neoplasm
KW - Polycythemia
KW - Splanchnic vein thrombosis
KW - Vera
KW - Young
UR - http://www.scopus.com/inward/record.url?scp=84879104781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879104781&partnerID=8YFLogxK
U2 - 10.3109/10428194.2012.759656
DO - 10.3109/10428194.2012.759656
M3 - Article
C2 - 23245211
AN - SCOPUS:84879104781
SN - 1042-8194
VL - 54
SP - 1989
EP - 1995
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 9
ER -
