Age-related loss of calbindin from human basal forebrain cholinergic neurons

Chuang Kuo Wu, M. Marsel Mesulam, Changiz Geula*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Loss of basal forebrain cholinergic neurons (BFCN) occurs in many age- related neurological diseases. Although age is the common risk factor in these disorders, no consistent age-related changes have been reported in the human BFCN. We investigated age-related alterations in choline acetyltransferase (ChAT), low-affinity nerve growth factor receptor (p75(LNGFR)) and calbindin-D(28k) (CalBP) immunoreactivity in the human BFCN. No significant age-related changes were observed in ChAT or p75(LNGFR) immunoreactivity. By contrast, normal aging was accompanied by a selective, substantial and significant loss of CalBP immunoreactivity from the BFCN. Other CalBP-positive neurons were unchanged. Loss of the calcium buffering capacity conferred by CalBP may leave the BFCN vulnerable to damage in neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)2209-2213
Number of pages5
Issue number9-10
StatePublished - 1997


  • Aging
  • Alzheimer's disease
  • Ca buffering
  • Calbindin-D(28k)
  • Choline acetyltransferase

ASJC Scopus subject areas

  • Neuroscience(all)


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