Abstract
Published data suggest that ketorolac pharmacokinetics are different in children than in adults. We sought to better characterize ketorolac pharmacokinetics in children. Thirty-six children, aged 1-16 yr, were stratified into four age groups: 1-3 yr, 4-7 yr, 8-11 yr, and 12-16 yr. Each child received 0.5 mg/kg of ketorolac tromethamine IV after completion of elective surgery. A maximum of 16 venous blood samples (mean, 13 ± 2) were collected at predetermined times up to 10 h after drug administration. Plasma ketorolac concentrations were measured by high-performance liquid chromatography after solid-phase extraction. Individual concentration-versus-time relationships were best fit to a two-compartment pharmacokinetic model by using SAAM II. Body weight-normalized pharmacokinetic variables did not differ among the age groups and were similar to those reported for adults, including a volume of distribution at steady state of 113 ± 33 mL/kg (mean ± SD) and an elimination clearance of 0.57 ± 0.17 mL · min-1 · kg-1. Our study demonstrates that a single dose of ketorolac (0.5 mg/kg) results in plasma concentrations in the adult therapeutic concentration range for 6 h in most children. Our data provide no evidence that children require either larger weightadjusted doses or shorter dosing intervals than adults to provide similar plasma drug concentrations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 266-270 |
| Number of pages | 5 |
| Journal | Anesthesia and analgesia |
| Volume | 94 |
| Issue number | 2 |
| State | Published - Feb 9 2002 |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
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Age-stratified pharmacokinetics of ketorolac tromethamine in pediatric surgical patients. / Dsida, Richard; Wheeler, Melissa; Birmingham, Patrick K; Wang, Zhao; Heffner, Corri L.; Coté, Charles J.; Avram, Michael J.
In: Anesthesia and analgesia, Vol. 94, No. 2, 09.02.2002, p. 266-270.Research output: Contribution to journal › Article
TY - JOUR
T1 - Age-stratified pharmacokinetics of ketorolac tromethamine in pediatric surgical patients
AU - Dsida, Richard
AU - Wheeler, Melissa
AU - Birmingham, Patrick K
AU - Wang, Zhao
AU - Heffner, Corri L.
AU - Coté, Charles J.
AU - Avram, Michael J
PY - 2002/2/9
Y1 - 2002/2/9
N2 - Published data suggest that ketorolac pharmacokinetics are different in children than in adults. We sought to better characterize ketorolac pharmacokinetics in children. Thirty-six children, aged 1-16 yr, were stratified into four age groups: 1-3 yr, 4-7 yr, 8-11 yr, and 12-16 yr. Each child received 0.5 mg/kg of ketorolac tromethamine IV after completion of elective surgery. A maximum of 16 venous blood samples (mean, 13 ± 2) were collected at predetermined times up to 10 h after drug administration. Plasma ketorolac concentrations were measured by high-performance liquid chromatography after solid-phase extraction. Individual concentration-versus-time relationships were best fit to a two-compartment pharmacokinetic model by using SAAM II. Body weight-normalized pharmacokinetic variables did not differ among the age groups and were similar to those reported for adults, including a volume of distribution at steady state of 113 ± 33 mL/kg (mean ± SD) and an elimination clearance of 0.57 ± 0.17 mL · min-1 · kg-1. Our study demonstrates that a single dose of ketorolac (0.5 mg/kg) results in plasma concentrations in the adult therapeutic concentration range for 6 h in most children. Our data provide no evidence that children require either larger weightadjusted doses or shorter dosing intervals than adults to provide similar plasma drug concentrations.
AB - Published data suggest that ketorolac pharmacokinetics are different in children than in adults. We sought to better characterize ketorolac pharmacokinetics in children. Thirty-six children, aged 1-16 yr, were stratified into four age groups: 1-3 yr, 4-7 yr, 8-11 yr, and 12-16 yr. Each child received 0.5 mg/kg of ketorolac tromethamine IV after completion of elective surgery. A maximum of 16 venous blood samples (mean, 13 ± 2) were collected at predetermined times up to 10 h after drug administration. Plasma ketorolac concentrations were measured by high-performance liquid chromatography after solid-phase extraction. Individual concentration-versus-time relationships were best fit to a two-compartment pharmacokinetic model by using SAAM II. Body weight-normalized pharmacokinetic variables did not differ among the age groups and were similar to those reported for adults, including a volume of distribution at steady state of 113 ± 33 mL/kg (mean ± SD) and an elimination clearance of 0.57 ± 0.17 mL · min-1 · kg-1. Our study demonstrates that a single dose of ketorolac (0.5 mg/kg) results in plasma concentrations in the adult therapeutic concentration range for 6 h in most children. Our data provide no evidence that children require either larger weightadjusted doses or shorter dosing intervals than adults to provide similar plasma drug concentrations.
UR - http://www.scopus.com/inward/record.url?scp=0036148852&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036148852&partnerID=8YFLogxK
M3 - Article
VL - 94
SP - 266
EP - 270
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 2
ER -