Aging and the kidney

W. W. Brown, B. B. Davis, L. A. Spry, N. Wongsurawat, J. D. Malone, D. T. Domoto

Research output: Contribution to journalReview articlepeer-review


Numerous anatomic and physiologic alterations occur in the kidney with aging. These changes affect the ability of elderly patient(s) to maintain homeostasis and alter response to medications, stress, illness, or changes in diet, mobility, or environment. Drug-induced illness and drug interactions are major problems in the elderly. Bone disease and fractures are associated with negative calcium balance and decreased production of 1,25-dihydrocholecalciferol seen with aging. The geriatric patient is not immune to the primary glomerular diseases that occur in younger patients, although the relative incidence of pathologic diagnoses may differ. The high incidence of membranous glomerulonephritis in the elderly, and the well-known association between malignancy and membranous nephropathy strongly favor aggressive evaluation of the nephrotic syndrome in the geriatric age group. Attention must be given to consideration of appropriate end-stage renal disease treatment alternatives for the geriatric population, which now comprises the fastest-growing segment of the end-stage renal disease population.

Original languageEnglish (US)
Pages (from-to)1790-1796
Number of pages7
JournalArchives of Internal Medicine
Issue number9
StatePublished - Nov 26 1986

ASJC Scopus subject areas

  • Internal Medicine


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