AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

Xiaojiang Gao, Arman Bashirova, Astrid K.N. Iversen, John Phair, James J. Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, Marcus Altfeld, Stephen J. O'Brien, Mary Carrington*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

162 Scopus citations

Abstract

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

Original languageEnglish (US)
Pages (from-to)1290-1292
Number of pages3
JournalNature Medicine
Volume11
Issue number12
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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