Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Anu Laulajainen-Hongisto*, Sanna Katriina Toppila-Salmi, Annika Luukkainen, Robert Kern

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.

Original languageEnglish (US)
Article number204
JournalFrontiers in Cell and Developmental Biology
Volume8
DOIs
StatePublished - Mar 27 2020

Keywords

  • allergic rhinitis (AR)
  • asthma
  • chronic rhinosinusitis
  • epithelium
  • inflammation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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