Airway pressure release ventilation during acute lung injury: A prospective multicenter trial

J. Rasanen*, R. D. Cane, J. B. Downs, J. M. Hurst, I. T. Jousela, R. R. Kirby, H. J. Rogove, M. C. Stock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Objective: To evaluate the feasibility of airway pressure release ventilation (APRV) in providing ventilatory support to patients with acute lung injury of diverse etiology and mild-to-moderate severity. Design: Prospective, multicenter, nonrandomized crossover trial. Setting: ICUs in six major referral hospitals. Patients: Fifty adult patients with respiratory failure requiring mechanical ventilation and positive end-expiratory airway pressure. Interventions: After optimization of continuous positive airway pressure (CPAP), conventional ventilation and APRV were administered sequentially for 30 mins. During APRV, the CPAP level and airway pressure release level were adjusted to prevent hypoxemia, while the degree of ventilatory support was adjusted by altering the frequency of pressure release. Measurements and Main Results: Circulatory and ventilatory pressures, arterial blood gases and pH, heart rate, and respiratory rate were measured. Alveolar ventilation was augmented adequately in 47 of 50 patients by APRV. Adjustment of APRV required an increase in mean CPAP from 13 ± 3 (SD) to 21 ± 9 cm H2O and a release pressure of 6 ± 5 cm H2O. This airway pressure pattern produced a mean airway pressure comparable to that pressure achieved during conventional ventilation. Failure of APRV in three patients could be attributed to an inadequate level of CPAP or an inadequate APRV rate. While maintaining oxygenation of arterial blood and circulatory function, APRV allowed a substantial (55 ± 17%; p < .0001) reduction in peak airway pressure compared with conventional positive pressure ventilation adjusted to deliver a comparable or lower level of ventilatory support. Conclusions: APRV is a feasible alternative to conventional mechanical ventilation for augmentation of alveolar ventilation in patients with acute lung injury of mild-to-moderate severity.

Original languageEnglish (US)
Pages (from-to)1234-1241
Number of pages8
JournalCritical care medicine
Issue number10
StatePublished - Jan 1 1991


  • Blood gas analysis
  • Critical care medicine
  • Injury, lung
  • Lung
  • Mortality
  • Positive-pressure respiration
  • Pulmonary disease
  • Respiration, artificial
  • Respiratory distress syndrome, adult
  • Ventilation, mechanical

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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