Airway response to leukotriene d4 in rhesus monkeys

Roy Patterson; Kathleen E. Harris; Lewis J. Smith; Paul A. Greenhergera; Martha A. Shaughnessy; Peter R. Bernstein; Robert D. Krell

doi:10.1159/000233380

Airway response to leukotriene d4 in rhesus monkeys

Roy Patterson^*, Kathleen E. Harris, Lewis J. Smith, Paul A. Greenhergera, Martha A. Shaughnessy, Peter R. Bernstein, Robert D. Krell

^*Corresponding author for this work

Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We studied the effect of leukotriene D4 (LTD4) given by aerosol challenge on asthmatic and normal monkeys. The response to LTD4 occurred within 2 min., was prolonged at higher concentrations, was reversed by epinephrine, and more closely resembled an antigen response than a histamine response. Since LTD4 concentrations of 30-100 µg/ml produced a response similar to 2-20 mg/ml of histamine, the LTD4 was 300-900 times as potent as histamine on a molar basis. Thus, LTD4, which appears to reproduce an antigen-induced response in rhesus monkeys, may be a mediator of allergic asthma in these animals.

Original language	English (US)
Pages (from-to)	156-160
Number of pages	5
Journal	International archives of allergy and immunology
Volume	71
Issue number	2
DOIs	https://doi.org/10.1159/000233380
State	Published - 1983

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Airway response to leukotriene d4 in rhesus monkeys",

abstract = "We studied the effect of leukotriene D4 (LTD4) given by aerosol challenge on asthmatic and normal monkeys. The response to LTD4 occurred within 2 min., was prolonged at higher concentrations, was reversed by epinephrine, and more closely resembled an antigen response than a histamine response. Since LTD4 concentrations of 30-100 µg/ml produced a response similar to 2-20 mg/ml of histamine, the LTD4 was 300-900 times as potent as histamine on a molar basis. Thus, LTD4, which appears to reproduce an antigen-induced response in rhesus monkeys, may be a mediator of allergic asthma in these animals.",

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AU - Patterson, Roy

AU - Harris, Kathleen E.

AU - Smith, Lewis J.

AU - Greenhergera, Paul A.

AU - Shaughnessy, Martha A.

AU - Bernstein, Peter R.

AU - Krell, Robert D.

PY - 1983

Y1 - 1983

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AB - We studied the effect of leukotriene D4 (LTD4) given by aerosol challenge on asthmatic and normal monkeys. The response to LTD4 occurred within 2 min., was prolonged at higher concentrations, was reversed by epinephrine, and more closely resembled an antigen response than a histamine response. Since LTD4 concentrations of 30-100 µg/ml produced a response similar to 2-20 mg/ml of histamine, the LTD4 was 300-900 times as potent as histamine on a molar basis. Thus, LTD4, which appears to reproduce an antigen-induced response in rhesus monkeys, may be a mediator of allergic asthma in these animals.

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Airway response to leukotriene d4 in rhesus monkeys

Abstract

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