Airway response to leukotriene d4 in rhesus monkeys

Roy Patterson*, Kathleen E. Harris, Lewis J. Smith, Paul A. Greenhergera, Martha A. Shaughnessy, Peter R. Bernstein, Robert D. Krell

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We studied the effect of leukotriene D4 (LTD4) given by aerosol challenge on asthmatic and normal monkeys. The response to LTD4 occurred within 2 min., was prolonged at higher concentrations, was reversed by epinephrine, and more closely resembled an antigen response than a histamine response. Since LTD4 concentrations of 30-100 µg/ml produced a response similar to 2-20 mg/ml of histamine, the LTD4 was 300-900 times as potent as histamine on a molar basis. Thus, LTD4, which appears to reproduce an antigen-induced response in rhesus monkeys, may be a mediator of allergic asthma in these animals.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalInternational archives of allergy and immunology
Volume71
Issue number2
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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