Akinesia in Parkinson's disease. II. Effects of subthreshold repetitive transcranial motor cortex stimulation

A. Pascual-Leone, J. Valls-Solé, J. P. Brasil-Neto, A. Cammarota, J. Grafman, M. Hallett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

252 Scopus citations

Abstract

We studied the effects of repetitive transcranial stimulation of the motor cortex (rTMS) on choice reaction time (cRT), movement time (MT), and error rate (ER) in a serial reaction-time task in six medicated patients with Parkinson's disease (PD) and 10 age-matched normal controls. In normal subjects, subthreshold 5-Hz rTMS did not significantly change cRT, slightly shortened MT, but increased ER. In the patients, rTMS significantly shortened cRT and MT without affecting ER. These effects did not impair procedural learning. Performance on a grooved peg-board test was improved by rTMS in the same PD patients, especially when they were off medications, but worsened in the normal subjects. Repetitive, subthreshold motor cortex stimulation can improve performance in patients with PD and could be useful therapeutically.

Original languageEnglish (US)
Pages (from-to)892-898
Number of pages7
JournalNeurology
Volume44
Issue number5
DOIs
StatePublished - May 1994

ASJC Scopus subject areas

  • Clinical Neurology

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