Albumin-induced resoprtion of fetal rat bone in vitro

Paula H. Stern

doi:10.1007/BF02062594

Albumin-induced resoprtion of fetal rat bone in vitro

Paula H. Stern^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Some serum albumins cause resorption of living bone in vitro. This effect of albumin is concentration-dependent. Dialyzed albumin and albumin heated at 55° retain full bone resorbing activity; heat denatured albumin is inactive. The albumin effect is inhibited by elevated pH. No correlation exists between bone resorbing activity and the capacity of albumins to bind calcium ions or to donate hydrogen ions. Thyrocalcitonin, glucagon, glucocorticoids and actinomycin D antagonize albumin-induced bone resorption.

Original language	English (US)
Pages (from-to)	67-75
Number of pages	9
Journal	Calcified Tissue Research
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/BF02062594
State	Published - Dec 1971

Keywords

Ablumin
Bone
Resorption

ASJC Scopus subject areas

Endocrinology

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AB - Some serum albumins cause resorption of living bone in vitro. This effect of albumin is concentration-dependent. Dialyzed albumin and albumin heated at 55° retain full bone resorbing activity; heat denatured albumin is inactive. The albumin effect is inhibited by elevated pH. No correlation exists between bone resorbing activity and the capacity of albumins to bind calcium ions or to donate hydrogen ions. Thyrocalcitonin, glucagon, glucocorticoids and actinomycin D antagonize albumin-induced bone resorption.

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KW - Bone

KW - Resorption

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Albumin-induced resoprtion of fetal rat bone in vitro

Abstract

Keywords

ASJC Scopus subject areas

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