Albumin-induced resoprtion of fetal rat bone in vitro

Paula H Stern*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Some serum albumins cause resorption of living bone in vitro. This effect of albumin is concentration-dependent. Dialyzed albumin and albumin heated at 55° retain full bone resorbing activity; heat denatured albumin is inactive. The albumin effect is inhibited by elevated pH. No correlation exists between bone resorbing activity and the capacity of albumins to bind calcium ions or to donate hydrogen ions. Thyrocalcitonin, glucagon, glucocorticoids and actinomycin D antagonize albumin-induced bone resorption.

Original languageEnglish (US)
Pages (from-to)67-75
Number of pages9
JournalCalcified Tissue Research
Volume7
Issue number1
DOIs
StatePublished - Dec 1 1971

Keywords

  • Ablumin
  • Bone
  • Resorption

ASJC Scopus subject areas

  • Endocrinology

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