Some serum albumins cause resorption of living bone in vitro. This effect of albumin is concentration-dependent. Dialyzed albumin and albumin heated at 55° retain full bone resorbing activity; heat denatured albumin is inactive. The albumin effect is inhibited by elevated pH. No correlation exists between bone resorbing activity and the capacity of albumins to bind calcium ions or to donate hydrogen ions. Thyrocalcitonin, glucagon, glucocorticoids and actinomycin D antagonize albumin-induced bone resorption.
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