Albumin Use in Brain-injured and Neurosurgical Patients: Concepts, Indications, and Controversies

Heung Kan Ma, John F. Bebawy*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Human albumin has been used extensively for decades as a nonwhole blood plasma replacement fluid in the perioperative and critical care setting. Its potential advantages as a highly effective volume expander must be weighed, however, against its potential harm for patients in the context of various neurological states and for various neurosurgical interventions. This narrative review explores the physiological considerations of intravenous human albumin as a replacement fluid and examines the extant clinical evidence for and against its use within the various facets of modern neuroanesthesia and neurocritical care practice.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalJournal of Neurosurgical Anesthesiology
Issue number4
StatePublished - Oct 1 2021


  • human serum albumin
  • intravenous infusion
  • neuroanesthesia
  • neurosurgery
  • neurosurgical anesthesia
  • perioperative care

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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