Alcohol consumption and subclinical atherosclerosis among South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study

Parag A. Chevli*, Amer I. Aladin, Alka M. Kanaya, Namratha R. Kandula, Diego Malaver, David M. Herrington

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: South Asians are the second fastest growing ethnic group in the United States, and they have a high risk for cardiovascular disease (CVD). Moderate alcohol consumption has been associated with lower CVD risk in some race/ethnic groups, but the association of alcohol consumption and atherosclerosis in South Asians has not been investigated. Methods and Results: We used data from 906 South Asian participants who participated in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort (2010–2012). Alcohol consumption was ascertained via questionnaire, coronary artery calcium (CAC) was measured with computed tomography, and common carotid artery intima-media thickness (cIMT) was measured using B-mode ultrasonography. We used multivariable regression models to examine cross-sectional associations of alcohol consumption with the presence and amount of CAC and cIMT. Compared with never drinkers, participants consuming 4–7 drinks/week had a 63% decreased odds of any CAC after adjusting for potential confounders and mediators. Participants consuming 4–7 drinks/week had significantly lower odds of CAC score between 1 and 300 [OR (95% CI): 0.34 (0.16–0.72)]. A similar inverse association was seen for the odds of CAC>300 [OR (95% CI): 0.28 (0.07–0.97)]. Alcohol consumption of >7 drinks/week was associated with a 0.096 mm increase in common-cIMT. Conclusion: There was an inverse association between the amount of alcohol intake and CAC among South Asians while a positive association was found between alcohol consumption and common-cIMT. Long-term follow-up of the MASALA cohort will examine prospective associations of alcohol intake with the progression of subclinical atherosclerosis, incident CVD events, and mortality.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume30
Issue number1
DOIs
StatePublished - Jan 3 2020

Fingerprint

Alcohol Drinking
Atherosclerosis
Coronary Vessels
Carotid Intima-Media Thickness
Calcium
Common Carotid Artery
Cardiovascular Diseases
Ethnic Groups
Alcohols
Carotid Arteries
Ultrasonography
Tomography
Mortality

Keywords

  • Alcohol
  • Coronary artery calcium
  • South Asian
  • Subclinical atherosclerosis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

@article{c0f94ae2ae3a4c37ae570608cfff20b0,
title = "Alcohol consumption and subclinical atherosclerosis among South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study",
abstract = "Background: South Asians are the second fastest growing ethnic group in the United States, and they have a high risk for cardiovascular disease (CVD). Moderate alcohol consumption has been associated with lower CVD risk in some race/ethnic groups, but the association of alcohol consumption and atherosclerosis in South Asians has not been investigated. Methods and Results: We used data from 906 South Asian participants who participated in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort (2010–2012). Alcohol consumption was ascertained via questionnaire, coronary artery calcium (CAC) was measured with computed tomography, and common carotid artery intima-media thickness (cIMT) was measured using B-mode ultrasonography. We used multivariable regression models to examine cross-sectional associations of alcohol consumption with the presence and amount of CAC and cIMT. Compared with never drinkers, participants consuming 4–7 drinks/week had a 63{\%} decreased odds of any CAC after adjusting for potential confounders and mediators. Participants consuming 4–7 drinks/week had significantly lower odds of CAC score between 1 and 300 [OR (95{\%} CI): 0.34 (0.16–0.72)]. A similar inverse association was seen for the odds of CAC>300 [OR (95{\%} CI): 0.28 (0.07–0.97)]. Alcohol consumption of >7 drinks/week was associated with a 0.096 mm increase in common-cIMT. Conclusion: There was an inverse association between the amount of alcohol intake and CAC among South Asians while a positive association was found between alcohol consumption and common-cIMT. Long-term follow-up of the MASALA cohort will examine prospective associations of alcohol intake with the progression of subclinical atherosclerosis, incident CVD events, and mortality.",
keywords = "Alcohol, Coronary artery calcium, South Asian, Subclinical atherosclerosis",
author = "Chevli, {Parag A.} and Aladin, {Amer I.} and Kanaya, {Alka M.} and Kandula, {Namratha R.} and Diego Malaver and Herrington, {David M.}",
year = "2020",
month = "1",
day = "3",
doi = "10.1016/j.numecd.2019.07.021",
language = "English (US)",
volume = "30",
pages = "123--131",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier",
number = "1",

}

Alcohol consumption and subclinical atherosclerosis among South Asians : Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. / Chevli, Parag A.; Aladin, Amer I.; Kanaya, Alka M.; Kandula, Namratha R.; Malaver, Diego; Herrington, David M.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 30, No. 1, 03.01.2020, p. 123-131.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alcohol consumption and subclinical atherosclerosis among South Asians

T2 - Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study

AU - Chevli, Parag A.

AU - Aladin, Amer I.

AU - Kanaya, Alka M.

AU - Kandula, Namratha R.

AU - Malaver, Diego

AU - Herrington, David M.

PY - 2020/1/3

Y1 - 2020/1/3

N2 - Background: South Asians are the second fastest growing ethnic group in the United States, and they have a high risk for cardiovascular disease (CVD). Moderate alcohol consumption has been associated with lower CVD risk in some race/ethnic groups, but the association of alcohol consumption and atherosclerosis in South Asians has not been investigated. Methods and Results: We used data from 906 South Asian participants who participated in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort (2010–2012). Alcohol consumption was ascertained via questionnaire, coronary artery calcium (CAC) was measured with computed tomography, and common carotid artery intima-media thickness (cIMT) was measured using B-mode ultrasonography. We used multivariable regression models to examine cross-sectional associations of alcohol consumption with the presence and amount of CAC and cIMT. Compared with never drinkers, participants consuming 4–7 drinks/week had a 63% decreased odds of any CAC after adjusting for potential confounders and mediators. Participants consuming 4–7 drinks/week had significantly lower odds of CAC score between 1 and 300 [OR (95% CI): 0.34 (0.16–0.72)]. A similar inverse association was seen for the odds of CAC>300 [OR (95% CI): 0.28 (0.07–0.97)]. Alcohol consumption of >7 drinks/week was associated with a 0.096 mm increase in common-cIMT. Conclusion: There was an inverse association between the amount of alcohol intake and CAC among South Asians while a positive association was found between alcohol consumption and common-cIMT. Long-term follow-up of the MASALA cohort will examine prospective associations of alcohol intake with the progression of subclinical atherosclerosis, incident CVD events, and mortality.

AB - Background: South Asians are the second fastest growing ethnic group in the United States, and they have a high risk for cardiovascular disease (CVD). Moderate alcohol consumption has been associated with lower CVD risk in some race/ethnic groups, but the association of alcohol consumption and atherosclerosis in South Asians has not been investigated. Methods and Results: We used data from 906 South Asian participants who participated in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort (2010–2012). Alcohol consumption was ascertained via questionnaire, coronary artery calcium (CAC) was measured with computed tomography, and common carotid artery intima-media thickness (cIMT) was measured using B-mode ultrasonography. We used multivariable regression models to examine cross-sectional associations of alcohol consumption with the presence and amount of CAC and cIMT. Compared with never drinkers, participants consuming 4–7 drinks/week had a 63% decreased odds of any CAC after adjusting for potential confounders and mediators. Participants consuming 4–7 drinks/week had significantly lower odds of CAC score between 1 and 300 [OR (95% CI): 0.34 (0.16–0.72)]. A similar inverse association was seen for the odds of CAC>300 [OR (95% CI): 0.28 (0.07–0.97)]. Alcohol consumption of >7 drinks/week was associated with a 0.096 mm increase in common-cIMT. Conclusion: There was an inverse association between the amount of alcohol intake and CAC among South Asians while a positive association was found between alcohol consumption and common-cIMT. Long-term follow-up of the MASALA cohort will examine prospective associations of alcohol intake with the progression of subclinical atherosclerosis, incident CVD events, and mortality.

KW - Alcohol

KW - Coronary artery calcium

KW - South Asian

KW - Subclinical atherosclerosis

UR - http://www.scopus.com/inward/record.url?scp=85075385570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075385570&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2019.07.021

DO - 10.1016/j.numecd.2019.07.021

M3 - Article

C2 - 31753783

AN - SCOPUS:85075385570

VL - 30

SP - 123

EP - 131

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 1

ER -