Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function

Alexander R. Mackie; Prasanna Krishnamurthy; Suresh K. Verma; Tina Thorne; Veronica Ramirez; Gangjian Qin; Tatiana Abramova; Hiromichi Hamada; Douglas W. Losordo; Raj Kishore

doi:10.1074/jbc.M113.468009

Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function

Alexander R. Mackie, Prasanna Krishnamurthy, Suresh K. Verma, Tina Thorne, Veronica Ramirez, Gangjian Qin, Tatiana Abramova, Hiromichi Hamada, Douglas W. Losordo, Raj Kishore^*

^*Corresponding author for this work

Medicine, Cardiology Division

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11 Scopus citations

Abstract

Background: Estrogen supplementation enhances voluntary alcohol consumption in ovariectomized rodents. The effects of the enhanced alcohol consumption on post-infarct myocardial repair are unknown. Results: Ethanol-mediated suppression of endothelial progenitor cells produces diminished post-ischemic left ventricular function. Conclusion: Estrogen-induced increases in alcohol consumption negatively compete with the cardioprotective effects of estrogen. Significance: Alcohol consumption during estrogen replacement therapy must be observed closely.

Original language	English (US)
Pages (from-to)	18022-18034
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	25
DOIs	https://doi.org/10.1074/jbc.M113.468009
State	Published - Jun 21 2013

Funding

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.468009

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Mackie, A. R., Krishnamurthy, P., Verma, S. K., Thorne, T., Ramirez, V., Qin, G., Abramova, T., Hamada, H., Losordo, D. W., & Kishore, R. (2013). Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function. Journal of Biological Chemistry, 288(25), 18022-18034. https://doi.org/10.1074/jbc.M113.468009

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title = "Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function",

abstract = "Background: Estrogen supplementation enhances voluntary alcohol consumption in ovariectomized rodents. The effects of the enhanced alcohol consumption on post-infarct myocardial repair are unknown. Results: Ethanol-mediated suppression of endothelial progenitor cells produces diminished post-ischemic left ventricular function. Conclusion: Estrogen-induced increases in alcohol consumption negatively compete with the cardioprotective effects of estrogen. Significance: Alcohol consumption during estrogen replacement therapy must be observed closely.",

author = "Mackie, {Alexander R.} and Prasanna Krishnamurthy and Verma, {Suresh K.} and Tina Thorne and Veronica Ramirez and Gangjian Qin and Tatiana Abramova and Hiromichi Hamada and Losordo, {Douglas W.} and Raj Kishore",

year = "2013",

month = jun,

day = "21",

doi = "10.1074/jbc.M113.468009",

language = "English (US)",

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Mackie, AR, Krishnamurthy, P, Verma, SK, Thorne, T, Ramirez, V, Qin, G, Abramova, T, Hamada, H, Losordo, DW & Kishore, R 2013, 'Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function', Journal of Biological Chemistry, vol. 288, no. 25, pp. 18022-18034. https://doi.org/10.1074/jbc.M113.468009

Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function. / Mackie, Alexander R.; Krishnamurthy, Prasanna; Verma, Suresh K. et al.
In: Journal of Biological Chemistry, Vol. 288, No. 25, 21.06.2013, p. 18022-18034.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function

AU - Mackie, Alexander R.

AU - Krishnamurthy, Prasanna

AU - Verma, Suresh K.

AU - Thorne, Tina

AU - Ramirez, Veronica

AU - Qin, Gangjian

AU - Abramova, Tatiana

AU - Hamada, Hiromichi

AU - Losordo, Douglas W.

AU - Kishore, Raj

PY - 2013/6/21

Y1 - 2013/6/21

N2 - Background: Estrogen supplementation enhances voluntary alcohol consumption in ovariectomized rodents. The effects of the enhanced alcohol consumption on post-infarct myocardial repair are unknown. Results: Ethanol-mediated suppression of endothelial progenitor cells produces diminished post-ischemic left ventricular function. Conclusion: Estrogen-induced increases in alcohol consumption negatively compete with the cardioprotective effects of estrogen. Significance: Alcohol consumption during estrogen replacement therapy must be observed closely.

AB - Background: Estrogen supplementation enhances voluntary alcohol consumption in ovariectomized rodents. The effects of the enhanced alcohol consumption on post-infarct myocardial repair are unknown. Results: Ethanol-mediated suppression of endothelial progenitor cells produces diminished post-ischemic left ventricular function. Conclusion: Estrogen-induced increases in alcohol consumption negatively compete with the cardioprotective effects of estrogen. Significance: Alcohol consumption during estrogen replacement therapy must be observed closely.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 25

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Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function

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