Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function

Alexander R. Mackie, Prasanna Krishnamurthy, Suresh K. Verma, Tina Thorne, Veronica Ramirez, Gangjian Qin, Tatiana Abramova, Hiromichi Hamada, Douglas W. Losordo, Raj Kishore*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Estrogen supplementation enhances voluntary alcohol consumption in ovariectomized rodents. The effects of the enhanced alcohol consumption on post-infarct myocardial repair are unknown. Results: Ethanol-mediated suppression of endothelial progenitor cells produces diminished post-ischemic left ventricular function. Conclusion: Estrogen-induced increases in alcohol consumption negatively compete with the cardioprotective effects of estrogen. Significance: Alcohol consumption during estrogen replacement therapy must be observed closely.

Original languageEnglish (US)
Pages (from-to)18022-18034
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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